Excitatory transmission at thalamo–striatal synapses mediates susceptibility to social stress

Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical in shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibit increased synaptic strength at intralaminar thalamus (ILT), but not...

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Detalles Bibliográficos
Autores principales: Christoffel, Daniel J., Golden, Sam A., Walsh, Jessica J., Guise, Kevin G., Heshmati, Mitra, Friedman, Allyson K., Dey, Aditi, Smith, Milo, Rebusi, Nicole, Pfau, Madeline, Ables, Jessica L., Hodes, Georgia E., Ben–Dor, Gabriel A., Deisseroth, Karl, Shapiro, Matthew L., Malenka, Robert C., Ibanez–Tallon, Ines, Hu–Han, Ming, Russo, Scott J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482771/
https://www.ncbi.nlm.nih.gov/pubmed/26030846
http://dx.doi.org/10.1038/nn.4034
Descripción
Sumario:Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical in shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibit increased synaptic strength at intralaminar thalamus (ILT), but not prefrontal cortex (PFC), inputs to vSTR MSNs following chronic social stress. Modulation of ILT–vSTR versus PFC–vSTR neuronal activity differentially regulates dendritic spine plasticity and social avoidance.

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