Excitatory transmission at thalamo–striatal synapses mediates susceptibility to social stress

Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical in shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibit increased synaptic strength at intralaminar thalamus (ILT), but not...

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Autores principales: Christoffel, Daniel J., Golden, Sam A., Walsh, Jessica J., Guise, Kevin G., Heshmati, Mitra, Friedman, Allyson K., Dey, Aditi, Smith, Milo, Rebusi, Nicole, Pfau, Madeline, Ables, Jessica L., Hodes, Georgia E., Ben–Dor, Gabriel A., Deisseroth, Karl, Shapiro, Matthew L., Malenka, Robert C., Ibanez–Tallon, Ines, Hu–Han, Ming, Russo, Scott J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482771/
https://www.ncbi.nlm.nih.gov/pubmed/26030846
http://dx.doi.org/10.1038/nn.4034
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author Christoffel, Daniel J.
Golden, Sam A.
Walsh, Jessica J.
Guise, Kevin G.
Heshmati, Mitra
Friedman, Allyson K.
Dey, Aditi
Smith, Milo
Rebusi, Nicole
Pfau, Madeline
Ables, Jessica L.
Hodes, Georgia E.
Ben–Dor, Gabriel A.
Deisseroth, Karl
Shapiro, Matthew L.
Malenka, Robert C.
Ibanez–Tallon, Ines
Hu–Han, Ming
Russo, Scott J.
author_facet Christoffel, Daniel J.
Golden, Sam A.
Walsh, Jessica J.
Guise, Kevin G.
Heshmati, Mitra
Friedman, Allyson K.
Dey, Aditi
Smith, Milo
Rebusi, Nicole
Pfau, Madeline
Ables, Jessica L.
Hodes, Georgia E.
Ben–Dor, Gabriel A.
Deisseroth, Karl
Shapiro, Matthew L.
Malenka, Robert C.
Ibanez–Tallon, Ines
Hu–Han, Ming
Russo, Scott J.
author_sort Christoffel, Daniel J.
collection PubMed
description Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical in shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibit increased synaptic strength at intralaminar thalamus (ILT), but not prefrontal cortex (PFC), inputs to vSTR MSNs following chronic social stress. Modulation of ILT–vSTR versus PFC–vSTR neuronal activity differentially regulates dendritic spine plasticity and social avoidance.
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spelling pubmed-44827712016-01-01 Excitatory transmission at thalamo–striatal synapses mediates susceptibility to social stress Christoffel, Daniel J. Golden, Sam A. Walsh, Jessica J. Guise, Kevin G. Heshmati, Mitra Friedman, Allyson K. Dey, Aditi Smith, Milo Rebusi, Nicole Pfau, Madeline Ables, Jessica L. Hodes, Georgia E. Ben–Dor, Gabriel A. Deisseroth, Karl Shapiro, Matthew L. Malenka, Robert C. Ibanez–Tallon, Ines Hu–Han, Ming Russo, Scott J. Nat Neurosci Article Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical in shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibit increased synaptic strength at intralaminar thalamus (ILT), but not prefrontal cortex (PFC), inputs to vSTR MSNs following chronic social stress. Modulation of ILT–vSTR versus PFC–vSTR neuronal activity differentially regulates dendritic spine plasticity and social avoidance. 2015-06-01 2015-07 /pmc/articles/PMC4482771/ /pubmed/26030846 http://dx.doi.org/10.1038/nn.4034 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Christoffel, Daniel J.
Golden, Sam A.
Walsh, Jessica J.
Guise, Kevin G.
Heshmati, Mitra
Friedman, Allyson K.
Dey, Aditi
Smith, Milo
Rebusi, Nicole
Pfau, Madeline
Ables, Jessica L.
Hodes, Georgia E.
Ben–Dor, Gabriel A.
Deisseroth, Karl
Shapiro, Matthew L.
Malenka, Robert C.
Ibanez–Tallon, Ines
Hu–Han, Ming
Russo, Scott J.
Excitatory transmission at thalamo–striatal synapses mediates susceptibility to social stress
title Excitatory transmission at thalamo–striatal synapses mediates susceptibility to social stress
title_full Excitatory transmission at thalamo–striatal synapses mediates susceptibility to social stress
title_fullStr Excitatory transmission at thalamo–striatal synapses mediates susceptibility to social stress
title_full_unstemmed Excitatory transmission at thalamo–striatal synapses mediates susceptibility to social stress
title_short Excitatory transmission at thalamo–striatal synapses mediates susceptibility to social stress
title_sort excitatory transmission at thalamo–striatal synapses mediates susceptibility to social stress
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482771/
https://www.ncbi.nlm.nih.gov/pubmed/26030846
http://dx.doi.org/10.1038/nn.4034
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