Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance

PICALM is highly validated genetic risk factor for Alzheimer’s disease (AD). Here, we report that PICALM reductions in AD and murine brain endothelium correlate with amyloid–β (Aβ) pathology and cognitive impairment. Moreover, Picalm deficiency diminishes Aβ clearance across the murine blood–brain b...

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Detalles Bibliográficos
Autores principales: Zhao, Zhen, Sagare, Abhay P., Ma, Qingyi, Halliday, Matthew R., Kong, Pan, Kisler, Kassandra, Winkler, Ethan A., Ramanathan, Anita, Kanekiyo, Takahisa, Bu, Guojun, Owens, Nelly Chuqui, Rege, Sanket V., Si, Gabriel, Ahuja, Ashim, Zhu, Donghui, Miller, Carol A., Schneider, Julie A., Maeda, Manami, Maeda, Takahiro, Sugawara, Tohru, Ichida, Justin K., Zlokovic, Berislav V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482781/
https://www.ncbi.nlm.nih.gov/pubmed/26005850
http://dx.doi.org/10.1038/nn.4025

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