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Resting State Brain Connectivity After Surgical and Behavioral Weight Loss
OBJECTIVE: We previously reported changes in food-cue neural reactivity associated with behavioral and surgical weight loss interventions. Resting functional connectivity represents tonic neural activity that may contribute to weight loss success. Here we explore whether intervention type is associa...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483156/ https://www.ncbi.nlm.nih.gov/pubmed/26053145 http://dx.doi.org/10.1002/oby.21119 |
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author | Lepping, Rebecca J. Bruce, Amanda S. Francisco, Alex Yeh, Hung-Wen Martin, Laura E. Powell, Joshua N. Hancock, Laura Patrician, Trisha M. Breslin, Florence J. Selim, Niazy Donnelly, Joseph E. Brooks, William M. Savage, Cary R. Simmons, W. Kyle Bruce, Jared M. |
author_facet | Lepping, Rebecca J. Bruce, Amanda S. Francisco, Alex Yeh, Hung-Wen Martin, Laura E. Powell, Joshua N. Hancock, Laura Patrician, Trisha M. Breslin, Florence J. Selim, Niazy Donnelly, Joseph E. Brooks, William M. Savage, Cary R. Simmons, W. Kyle Bruce, Jared M. |
author_sort | Lepping, Rebecca J. |
collection | PubMed |
description | OBJECTIVE: We previously reported changes in food-cue neural reactivity associated with behavioral and surgical weight loss interventions. Resting functional connectivity represents tonic neural activity that may contribute to weight loss success. Here we explore whether intervention type is associated with differences in functional connectivity after weight loss. METHODS: Fifteen obese participants were recruited prior to adjustable gastric banding surgery. Thirteen demographically matched obese participants were selected from a separate behavioral diet intervention. Resting state fMRI was collected three months after surgery/behavioral intervention. ANOVA was used to examine post-weight loss differences between the two groups in connectivity to seed regions previously identified as showing differential cue-reactivity after weight loss. RESULTS: Following weight loss, behavioral dieters exhibited increased connectivity between left precuneus/superior parietal lobule (SPL) and bilateral insula pre- to post-meal and bariatric patients exhibited decreased connectivity between these regions pre- to post-meal (p(corrected)<.05). CONCLUSIONS: Behavioral dieters showed increased connectivity pre- to post-meal between a region associated with processing of self-referent information (precuneus/SPL) and a region associated with interoception (insula) whereas bariatric patients showed decreased connectivity between these regions. This may reflect increased attention to hunger signals following surgical procedures, and increased attention to satiety signals following behavioral diet interventions. |
format | Online Article Text |
id | pubmed-4483156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-44831562016-05-18 Resting State Brain Connectivity After Surgical and Behavioral Weight Loss Lepping, Rebecca J. Bruce, Amanda S. Francisco, Alex Yeh, Hung-Wen Martin, Laura E. Powell, Joshua N. Hancock, Laura Patrician, Trisha M. Breslin, Florence J. Selim, Niazy Donnelly, Joseph E. Brooks, William M. Savage, Cary R. Simmons, W. Kyle Bruce, Jared M. Obesity (Silver Spring) Article OBJECTIVE: We previously reported changes in food-cue neural reactivity associated with behavioral and surgical weight loss interventions. Resting functional connectivity represents tonic neural activity that may contribute to weight loss success. Here we explore whether intervention type is associated with differences in functional connectivity after weight loss. METHODS: Fifteen obese participants were recruited prior to adjustable gastric banding surgery. Thirteen demographically matched obese participants were selected from a separate behavioral diet intervention. Resting state fMRI was collected three months after surgery/behavioral intervention. ANOVA was used to examine post-weight loss differences between the two groups in connectivity to seed regions previously identified as showing differential cue-reactivity after weight loss. RESULTS: Following weight loss, behavioral dieters exhibited increased connectivity between left precuneus/superior parietal lobule (SPL) and bilateral insula pre- to post-meal and bariatric patients exhibited decreased connectivity between these regions pre- to post-meal (p(corrected)<.05). CONCLUSIONS: Behavioral dieters showed increased connectivity pre- to post-meal between a region associated with processing of self-referent information (precuneus/SPL) and a region associated with interoception (insula) whereas bariatric patients showed decreased connectivity between these regions. This may reflect increased attention to hunger signals following surgical procedures, and increased attention to satiety signals following behavioral diet interventions. 2015-06-05 2015-07 /pmc/articles/PMC4483156/ /pubmed/26053145 http://dx.doi.org/10.1002/oby.21119 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Lepping, Rebecca J. Bruce, Amanda S. Francisco, Alex Yeh, Hung-Wen Martin, Laura E. Powell, Joshua N. Hancock, Laura Patrician, Trisha M. Breslin, Florence J. Selim, Niazy Donnelly, Joseph E. Brooks, William M. Savage, Cary R. Simmons, W. Kyle Bruce, Jared M. Resting State Brain Connectivity After Surgical and Behavioral Weight Loss |
title | Resting State Brain Connectivity After Surgical and Behavioral Weight Loss |
title_full | Resting State Brain Connectivity After Surgical and Behavioral Weight Loss |
title_fullStr | Resting State Brain Connectivity After Surgical and Behavioral Weight Loss |
title_full_unstemmed | Resting State Brain Connectivity After Surgical and Behavioral Weight Loss |
title_short | Resting State Brain Connectivity After Surgical and Behavioral Weight Loss |
title_sort | resting state brain connectivity after surgical and behavioral weight loss |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483156/ https://www.ncbi.nlm.nih.gov/pubmed/26053145 http://dx.doi.org/10.1002/oby.21119 |
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