Knockdown of SUMO-activating enzyme subunit 2 (SAE2) suppresses cancer malignancy and enhances chemotherapy sensitivity in small cell lung cancer

BACKGROUND: SUMO-activating enzyme subunit 2 (SAE2) is the sole E1-activating enzyme required for numerous important protein SUMOylation, abnormal of which is associated with carcinogenesis. SAE2 inactivation was recently reported to be a therapeutic strategy in cancers with Myc overexpression. Howe...

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Detalles Bibliográficos
Autores principales: Liu, Xiaoke, Xu, Yong, Pang, Zongguo, Guo, Fuchun, Qin, Qing, Yin, Tao, Sang, Yaxiong, Feng, Chengjun, Li, Xiaoyu, Jiang, Li, Shu, Pei, Wang, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483218/
https://www.ncbi.nlm.nih.gov/pubmed/26063074
http://dx.doi.org/10.1186/s13045-015-0164-y

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