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Longitudinal study of bone loss in chronic spinal cord injury patients
[Purpose] This prospective longitudinal study evaluated the changes in bone metabolism markers and bone mineral density of spinal cord injury patients over 3 years. We also assessed the relationships among the bone mineral density, bone metabolism, and clinical data of spinal cord injury patients. [...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Society of Physical Therapy Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483412/ https://www.ncbi.nlm.nih.gov/pubmed/26157234 http://dx.doi.org/10.1589/jpts.27.1429 |
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author | Karapolat, Inanc Karapolat, Hale Uzumcugil Kirazli, Yesim Capaci, Kazim Akkoc, Yesim Kumanlioglu, Kamil |
author_facet | Karapolat, Inanc Karapolat, Hale Uzumcugil Kirazli, Yesim Capaci, Kazim Akkoc, Yesim Kumanlioglu, Kamil |
author_sort | Karapolat, Inanc |
collection | PubMed |
description | [Purpose] This prospective longitudinal study evaluated the changes in bone metabolism markers and bone mineral density of spinal cord injury patients over 3 years. We also assessed the relationships among the bone mineral density, bone metabolism, and clinical data of spinal cord injury patients. [Subjects and Methods] We assessed the clinical data (i.e., immobilization due to surgery, neurological status, neurological level, and extent of lesion) in 20 spinal cord injury patients. Bone mineral density, and hormonal and biochemical markers of the patients were measured at 0, 6, 12, and 36 months. [Results] Femoral neck T score decreased significantly at 36 months (p < 0.05). Among the hormonal markers, parathyroid hormone and vitamin D were significantly elevated, while bone turnover markers (i.e., deoxypyridinoline and osteocalcin) were significantly decreased at 12 and 36 months (p < 0.05). [Conclusion] Bone mineral density of the femoral neck decreases significantly during the long-term follow-up of patients with spinal cord injury due to osteoporosis. This could be due to changes in hormonal and bone turnover markers. |
format | Online Article Text |
id | pubmed-4483412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Society of Physical Therapy Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44834122015-07-08 Longitudinal study of bone loss in chronic spinal cord injury patients Karapolat, Inanc Karapolat, Hale Uzumcugil Kirazli, Yesim Capaci, Kazim Akkoc, Yesim Kumanlioglu, Kamil J Phys Ther Sci Original Article [Purpose] This prospective longitudinal study evaluated the changes in bone metabolism markers and bone mineral density of spinal cord injury patients over 3 years. We also assessed the relationships among the bone mineral density, bone metabolism, and clinical data of spinal cord injury patients. [Subjects and Methods] We assessed the clinical data (i.e., immobilization due to surgery, neurological status, neurological level, and extent of lesion) in 20 spinal cord injury patients. Bone mineral density, and hormonal and biochemical markers of the patients were measured at 0, 6, 12, and 36 months. [Results] Femoral neck T score decreased significantly at 36 months (p < 0.05). Among the hormonal markers, parathyroid hormone and vitamin D were significantly elevated, while bone turnover markers (i.e., deoxypyridinoline and osteocalcin) were significantly decreased at 12 and 36 months (p < 0.05). [Conclusion] Bone mineral density of the femoral neck decreases significantly during the long-term follow-up of patients with spinal cord injury due to osteoporosis. This could be due to changes in hormonal and bone turnover markers. The Society of Physical Therapy Science 2015-05-26 2015-05 /pmc/articles/PMC4483412/ /pubmed/26157234 http://dx.doi.org/10.1589/jpts.27.1429 Text en 2015©by the Society of Physical Therapy Science. Published by IPEC Inc. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Original Article Karapolat, Inanc Karapolat, Hale Uzumcugil Kirazli, Yesim Capaci, Kazim Akkoc, Yesim Kumanlioglu, Kamil Longitudinal study of bone loss in chronic spinal cord injury patients |
title | Longitudinal study of bone loss in chronic spinal cord injury
patients |
title_full | Longitudinal study of bone loss in chronic spinal cord injury
patients |
title_fullStr | Longitudinal study of bone loss in chronic spinal cord injury
patients |
title_full_unstemmed | Longitudinal study of bone loss in chronic spinal cord injury
patients |
title_short | Longitudinal study of bone loss in chronic spinal cord injury
patients |
title_sort | longitudinal study of bone loss in chronic spinal cord injury
patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483412/ https://www.ncbi.nlm.nih.gov/pubmed/26157234 http://dx.doi.org/10.1589/jpts.27.1429 |
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