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Prognostic value of neutrophil-to-lymphocyte ratio in breast cancer
Inflammation is an essential component of pathogenesis and progression of cancer. A high neutrophil-to-lymphocyte ratio (NLR) is considered as a prognostic indicator for breast cancer. This meta-analysis was conducted to establish the overall accuracy of the NLR test in the diagnosis of breast cance...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483486/ https://www.ncbi.nlm.nih.gov/pubmed/26137435 http://dx.doi.org/10.1016/j.fob.2015.05.003 |
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author | Chen, Jie Deng, Qiwen Pan, Yuqin He, Bangshun Ying, Houqun Sun, Huiling Liu, Xian Wang, Shukui |
author_facet | Chen, Jie Deng, Qiwen Pan, Yuqin He, Bangshun Ying, Houqun Sun, Huiling Liu, Xian Wang, Shukui |
author_sort | Chen, Jie |
collection | PubMed |
description | Inflammation is an essential component of pathogenesis and progression of cancer. A high neutrophil-to-lymphocyte ratio (NLR) is considered as a prognostic indicator for breast cancer. This meta-analysis was conducted to establish the overall accuracy of the NLR test in the diagnosis of breast cancer. A comprehensive search of the literature was conducted by using PubMed, Web of Science and China National Knowledge Infrastructure (CNKI). Published studies dating up to July 2014 and 4,293 patients were enrolled in the present study. In order to evaluate the association between NLR and overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) or cancer specific survival (CSS), the hazard ratios (HRs) and their 95% confidence intervals (CIs) were extracted. OS was the primary outcome. The results suggested that increased NLR was a strong predictor for OS with HR of 2.28 (95% CI = 1.08–4.80, P(heterogeneity) < 0.001). Stratified analyses indicated that a high NLR appeared to be a negative prognostic marker in Caucasian populations (HR = 4.53, 95% CI = 3.11–6.60, P(heterogeneity) = 0.096), multivariate analysis method (HR = 2.10, 95% CI = 1.52–2.89, P(heterogeneity) = 0.591), and mixed metastasis (HR = 4.53, 95% CI = 3.11–6.60, P(heterogeneity) = 0.096). Elevated NLR was associated with a high risk for DFS (HR = 1.38, 95% CI = 1.09–1.74, P(heterogeneity) = 0.050) and in subgroups of multivariate analysis (HR = 1.64, 95% CI = 1.25–2.14, P(heterogeneity) = 0.545) and mixed metastasis (HR = 1.99, 95% CI = 1.28–3.09, P(heterogeneity) = 0.992). In summary, NLR could be considered as a predictive factor for patients with breast cancer. |
format | Online Article Text |
id | pubmed-4483486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-44834862015-07-01 Prognostic value of neutrophil-to-lymphocyte ratio in breast cancer Chen, Jie Deng, Qiwen Pan, Yuqin He, Bangshun Ying, Houqun Sun, Huiling Liu, Xian Wang, Shukui FEBS Open Bio Research article Inflammation is an essential component of pathogenesis and progression of cancer. A high neutrophil-to-lymphocyte ratio (NLR) is considered as a prognostic indicator for breast cancer. This meta-analysis was conducted to establish the overall accuracy of the NLR test in the diagnosis of breast cancer. A comprehensive search of the literature was conducted by using PubMed, Web of Science and China National Knowledge Infrastructure (CNKI). Published studies dating up to July 2014 and 4,293 patients were enrolled in the present study. In order to evaluate the association between NLR and overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) or cancer specific survival (CSS), the hazard ratios (HRs) and their 95% confidence intervals (CIs) were extracted. OS was the primary outcome. The results suggested that increased NLR was a strong predictor for OS with HR of 2.28 (95% CI = 1.08–4.80, P(heterogeneity) < 0.001). Stratified analyses indicated that a high NLR appeared to be a negative prognostic marker in Caucasian populations (HR = 4.53, 95% CI = 3.11–6.60, P(heterogeneity) = 0.096), multivariate analysis method (HR = 2.10, 95% CI = 1.52–2.89, P(heterogeneity) = 0.591), and mixed metastasis (HR = 4.53, 95% CI = 3.11–6.60, P(heterogeneity) = 0.096). Elevated NLR was associated with a high risk for DFS (HR = 1.38, 95% CI = 1.09–1.74, P(heterogeneity) = 0.050) and in subgroups of multivariate analysis (HR = 1.64, 95% CI = 1.25–2.14, P(heterogeneity) = 0.545) and mixed metastasis (HR = 1.99, 95% CI = 1.28–3.09, P(heterogeneity) = 0.992). In summary, NLR could be considered as a predictive factor for patients with breast cancer. Elsevier 2015-05-12 /pmc/articles/PMC4483486/ /pubmed/26137435 http://dx.doi.org/10.1016/j.fob.2015.05.003 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research article Chen, Jie Deng, Qiwen Pan, Yuqin He, Bangshun Ying, Houqun Sun, Huiling Liu, Xian Wang, Shukui Prognostic value of neutrophil-to-lymphocyte ratio in breast cancer |
title | Prognostic value of neutrophil-to-lymphocyte ratio in breast cancer |
title_full | Prognostic value of neutrophil-to-lymphocyte ratio in breast cancer |
title_fullStr | Prognostic value of neutrophil-to-lymphocyte ratio in breast cancer |
title_full_unstemmed | Prognostic value of neutrophil-to-lymphocyte ratio in breast cancer |
title_short | Prognostic value of neutrophil-to-lymphocyte ratio in breast cancer |
title_sort | prognostic value of neutrophil-to-lymphocyte ratio in breast cancer |
topic | Research article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483486/ https://www.ncbi.nlm.nih.gov/pubmed/26137435 http://dx.doi.org/10.1016/j.fob.2015.05.003 |
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