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Severe, Persistent and Fatal Delirium in Psychogeriatric Patients Admitted to a Psychiatric Hospital

BACKGROUND/AIMS: Although delirium is generally regarded as a transient syndrome, persistence of delirium in patients with cognitive impairment – even with fatal outcome – has been reported as well. This study aims to describe the clinical features and neuropathological correlates of this type of de...

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Autores principales: Jans, Ingrid S., Oudewortel, Letty, Brandt, Paulien M., van Gool, Willem A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483487/
https://www.ncbi.nlm.nih.gov/pubmed/26195981
http://dx.doi.org/10.1159/000381847
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author Jans, Ingrid S.
Oudewortel, Letty
Brandt, Paulien M.
van Gool, Willem A.
author_facet Jans, Ingrid S.
Oudewortel, Letty
Brandt, Paulien M.
van Gool, Willem A.
author_sort Jans, Ingrid S.
collection PubMed
description BACKGROUND/AIMS: Although delirium is generally regarded as a transient syndrome, persistence of delirium in patients with cognitive impairment – even with fatal outcome – has been reported as well. This study aims to describe the clinical features and neuropathological correlates of this type of delirium. METHODS: Inclusion criteria for this case series were: (1) severe persistent delirium until death, (2) history of cognitive decline and (3) consent for brain autopsy. Medical records were examined in combination with collected clinical data and neuropathological findings. RESULT: In 15 patients, all living at home before admission, episodes with delirium lasted for 4.2 months on average. No distinct medical causes of persistent delirium could be identified. Pathological diagnoses included Alzheimer's disease and dementia with Lewy bodies as well as single cases of Creutzfeldt-Jakob disease and progressive supranuclear palsy. CONCLUSION: Severe, persistent and fatal delirium in patients with cognitive impairment can occur relatively early in the disease trajectory and is associated with diverse neuropathologies.
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spelling pubmed-44834872015-07-20 Severe, Persistent and Fatal Delirium in Psychogeriatric Patients Admitted to a Psychiatric Hospital Jans, Ingrid S. Oudewortel, Letty Brandt, Paulien M. van Gool, Willem A. Dement Geriatr Cogn Dis Extra Original Research Article BACKGROUND/AIMS: Although delirium is generally regarded as a transient syndrome, persistence of delirium in patients with cognitive impairment – even with fatal outcome – has been reported as well. This study aims to describe the clinical features and neuropathological correlates of this type of delirium. METHODS: Inclusion criteria for this case series were: (1) severe persistent delirium until death, (2) history of cognitive decline and (3) consent for brain autopsy. Medical records were examined in combination with collected clinical data and neuropathological findings. RESULT: In 15 patients, all living at home before admission, episodes with delirium lasted for 4.2 months on average. No distinct medical causes of persistent delirium could be identified. Pathological diagnoses included Alzheimer's disease and dementia with Lewy bodies as well as single cases of Creutzfeldt-Jakob disease and progressive supranuclear palsy. CONCLUSION: Severe, persistent and fatal delirium in patients with cognitive impairment can occur relatively early in the disease trajectory and is associated with diverse neuropathologies. S. Karger AG 2015-06-10 /pmc/articles/PMC4483487/ /pubmed/26195981 http://dx.doi.org/10.1159/000381847 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Original Research Article
Jans, Ingrid S.
Oudewortel, Letty
Brandt, Paulien M.
van Gool, Willem A.
Severe, Persistent and Fatal Delirium in Psychogeriatric Patients Admitted to a Psychiatric Hospital
title Severe, Persistent and Fatal Delirium in Psychogeriatric Patients Admitted to a Psychiatric Hospital
title_full Severe, Persistent and Fatal Delirium in Psychogeriatric Patients Admitted to a Psychiatric Hospital
title_fullStr Severe, Persistent and Fatal Delirium in Psychogeriatric Patients Admitted to a Psychiatric Hospital
title_full_unstemmed Severe, Persistent and Fatal Delirium in Psychogeriatric Patients Admitted to a Psychiatric Hospital
title_short Severe, Persistent and Fatal Delirium in Psychogeriatric Patients Admitted to a Psychiatric Hospital
title_sort severe, persistent and fatal delirium in psychogeriatric patients admitted to a psychiatric hospital
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483487/
https://www.ncbi.nlm.nih.gov/pubmed/26195981
http://dx.doi.org/10.1159/000381847
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