Cargando…

A Cluster Randomized Controlled Trial of Nonpharmacological Interventions for Old-Old Subjects with a Clinical Dementia Rating of 0.5: The Kurihara Project

BACKGROUND: Evidence as to the benefits of nonpharmacological interventions for the boundary state between normal aging and dementia [mild cognitive impairment or a Clinical Dementia Rating (CDR) of 0.5] remains weak due to a lack of positive controls. AIMS: To directly compare the effects of cognit...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakatsuka, Masahiro, Nakamura, Kei, Hamanosono, Ryo, Takahashi, Yumi, Kasai, Mari, Sato, Yuko, Suto, Teiko, Nagatomi, Ryoichi, Meguro, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483494/
https://www.ncbi.nlm.nih.gov/pubmed/26195978
http://dx.doi.org/10.1159/000380816
_version_ 1782378569034366976
author Nakatsuka, Masahiro
Nakamura, Kei
Hamanosono, Ryo
Takahashi, Yumi
Kasai, Mari
Sato, Yuko
Suto, Teiko
Nagatomi, Ryoichi
Meguro, Kenichi
author_facet Nakatsuka, Masahiro
Nakamura, Kei
Hamanosono, Ryo
Takahashi, Yumi
Kasai, Mari
Sato, Yuko
Suto, Teiko
Nagatomi, Ryoichi
Meguro, Kenichi
author_sort Nakatsuka, Masahiro
collection PubMed
description BACKGROUND: Evidence as to the benefits of nonpharmacological interventions for the boundary state between normal aging and dementia [mild cognitive impairment or a Clinical Dementia Rating (CDR) of 0.5] remains weak due to a lack of positive controls. AIMS: To directly compare the effects of cognitive interventions (CI), physical activities (PA) and a group reminiscence approach (GRA), we conducted a pilot study on the basis of a cluster randomized controlled trial design. METHOD: A total of 127 participants aged >74 years with a CDR of 0.5 were cluster randomized into three groups for CI, PA and GRA. The intervention lasted 12 weeks and consisted of weekly group sessions and home assignments. Mini-Mental State Examination (MMSE), Trail Making Test part A (TMT-A), word fluency (WF), 6-meter walk time and Quality of Life (QOL) Face Scale scores were evaluated as primary outcomes. RESULTS: Methodology-related benefits of CI and PA were found for MMSE scores and walk time, respectively. TMT-A, WF and QOL Face Scale scores improved irrespective of the methodologies used. CONCLUSIONS: Our findings suggest that CI and PA may be beneficial to cognitive and physical abilities, respectively. Executive functions and QOL may improve irrespective of the intervention methodologies used.
format Online
Article
Text
id pubmed-4483494
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-44834942015-07-20 A Cluster Randomized Controlled Trial of Nonpharmacological Interventions for Old-Old Subjects with a Clinical Dementia Rating of 0.5: The Kurihara Project Nakatsuka, Masahiro Nakamura, Kei Hamanosono, Ryo Takahashi, Yumi Kasai, Mari Sato, Yuko Suto, Teiko Nagatomi, Ryoichi Meguro, Kenichi Dement Geriatr Cogn Dis Extra Original Research Article BACKGROUND: Evidence as to the benefits of nonpharmacological interventions for the boundary state between normal aging and dementia [mild cognitive impairment or a Clinical Dementia Rating (CDR) of 0.5] remains weak due to a lack of positive controls. AIMS: To directly compare the effects of cognitive interventions (CI), physical activities (PA) and a group reminiscence approach (GRA), we conducted a pilot study on the basis of a cluster randomized controlled trial design. METHOD: A total of 127 participants aged >74 years with a CDR of 0.5 were cluster randomized into three groups for CI, PA and GRA. The intervention lasted 12 weeks and consisted of weekly group sessions and home assignments. Mini-Mental State Examination (MMSE), Trail Making Test part A (TMT-A), word fluency (WF), 6-meter walk time and Quality of Life (QOL) Face Scale scores were evaluated as primary outcomes. RESULTS: Methodology-related benefits of CI and PA were found for MMSE scores and walk time, respectively. TMT-A, WF and QOL Face Scale scores improved irrespective of the methodologies used. CONCLUSIONS: Our findings suggest that CI and PA may be beneficial to cognitive and physical abilities, respectively. Executive functions and QOL may improve irrespective of the intervention methodologies used. S. Karger AG 2015-05-30 /pmc/articles/PMC4483494/ /pubmed/26195978 http://dx.doi.org/10.1159/000380816 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Original Research Article
Nakatsuka, Masahiro
Nakamura, Kei
Hamanosono, Ryo
Takahashi, Yumi
Kasai, Mari
Sato, Yuko
Suto, Teiko
Nagatomi, Ryoichi
Meguro, Kenichi
A Cluster Randomized Controlled Trial of Nonpharmacological Interventions for Old-Old Subjects with a Clinical Dementia Rating of 0.5: The Kurihara Project
title A Cluster Randomized Controlled Trial of Nonpharmacological Interventions for Old-Old Subjects with a Clinical Dementia Rating of 0.5: The Kurihara Project
title_full A Cluster Randomized Controlled Trial of Nonpharmacological Interventions for Old-Old Subjects with a Clinical Dementia Rating of 0.5: The Kurihara Project
title_fullStr A Cluster Randomized Controlled Trial of Nonpharmacological Interventions for Old-Old Subjects with a Clinical Dementia Rating of 0.5: The Kurihara Project
title_full_unstemmed A Cluster Randomized Controlled Trial of Nonpharmacological Interventions for Old-Old Subjects with a Clinical Dementia Rating of 0.5: The Kurihara Project
title_short A Cluster Randomized Controlled Trial of Nonpharmacological Interventions for Old-Old Subjects with a Clinical Dementia Rating of 0.5: The Kurihara Project
title_sort cluster randomized controlled trial of nonpharmacological interventions for old-old subjects with a clinical dementia rating of 0.5: the kurihara project
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483494/
https://www.ncbi.nlm.nih.gov/pubmed/26195978
http://dx.doi.org/10.1159/000380816
work_keys_str_mv AT nakatsukamasahiro aclusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT nakamurakei aclusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT hamanosonoryo aclusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT takahashiyumi aclusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT kasaimari aclusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT satoyuko aclusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT sutoteiko aclusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT nagatomiryoichi aclusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT megurokenichi aclusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT nakatsukamasahiro clusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT nakamurakei clusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT hamanosonoryo clusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT takahashiyumi clusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT kasaimari clusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT satoyuko clusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT sutoteiko clusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT nagatomiryoichi clusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject
AT megurokenichi clusterrandomizedcontrolledtrialofnonpharmacologicalinterventionsforoldoldsubjectswithaclinicaldementiaratingof05thekuriharaproject