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Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays

Scrapie is diagnosed antemortem in sheep by detecting misfolded isoforms of prion protein (PrP(Sc)) in lymphoid follicles of the rectal mucosa and nictitating membranes. Assay sensitivity is limited if (a) the biopsy is collected early during disease development, (b) an insufficient number of follic...

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Detalles Bibliográficos
Autores principales:	Dassanayake, Rohana P., Truscott, Thomas C., Zhuang, Dongyue, Schneider, David A., Madsen-Bouterse, Sally A., Young, Alan J., Stanton, James B., Davis, William C., O'Rourke, Katherine I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Veterinary Science 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483501/ https://www.ncbi.nlm.nih.gov/pubmed/25549221 http://dx.doi.org/10.4142/jvs.2015.16.2.179

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