Myrothecols G and H, Two New Analogues of the Marine-Derived Quinone Sesquiterpene Penicilliumin A

Two new quinone sesquiterpenes named myrothecols G and H (1 and 2), a pair of C-1′ diastereomers of 13-hydroxyl penicilliumin A, were isolated from the mycelia solid cultures of Myrothecium sp. SC0265. Their structures, including the absolute configurations, were established on the basis of the spec...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Ying, Wu, Ping, Xue, Jinghua, Li, Hanxiang, Wei, Xiaoyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483633/
https://www.ncbi.nlm.nih.gov/pubmed/26023841
http://dx.doi.org/10.3390/md13063360
_version_ 1782378586524614656
author Fu, Ying
Wu, Ping
Xue, Jinghua
Li, Hanxiang
Wei, Xiaoyi
author_facet Fu, Ying
Wu, Ping
Xue, Jinghua
Li, Hanxiang
Wei, Xiaoyi
author_sort Fu, Ying
collection PubMed
description Two new quinone sesquiterpenes named myrothecols G and H (1 and 2), a pair of C-1′ diastereomers of 13-hydroxyl penicilliumin A, were isolated from the mycelia solid cultures of Myrothecium sp. SC0265. Their structures, including the absolute configurations, were established on the basis of the spectroscopic data combining with the theoretical conformational analysis. The cytotoxic activities of 1 and 2 were tested against a panel of human tumor cell lines.
format Online
Article
Text
id pubmed-4483633
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-44836332015-06-30 Myrothecols G and H, Two New Analogues of the Marine-Derived Quinone Sesquiterpene Penicilliumin A Fu, Ying Wu, Ping Xue, Jinghua Li, Hanxiang Wei, Xiaoyi Mar Drugs Article Two new quinone sesquiterpenes named myrothecols G and H (1 and 2), a pair of C-1′ diastereomers of 13-hydroxyl penicilliumin A, were isolated from the mycelia solid cultures of Myrothecium sp. SC0265. Their structures, including the absolute configurations, were established on the basis of the spectroscopic data combining with the theoretical conformational analysis. The cytotoxic activities of 1 and 2 were tested against a panel of human tumor cell lines. MDPI 2015-05-27 /pmc/articles/PMC4483633/ /pubmed/26023841 http://dx.doi.org/10.3390/md13063360 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fu, Ying
Wu, Ping
Xue, Jinghua
Li, Hanxiang
Wei, Xiaoyi
Myrothecols G and H, Two New Analogues of the Marine-Derived Quinone Sesquiterpene Penicilliumin A
title Myrothecols G and H, Two New Analogues of the Marine-Derived Quinone Sesquiterpene Penicilliumin A
title_full Myrothecols G and H, Two New Analogues of the Marine-Derived Quinone Sesquiterpene Penicilliumin A
title_fullStr Myrothecols G and H, Two New Analogues of the Marine-Derived Quinone Sesquiterpene Penicilliumin A
title_full_unstemmed Myrothecols G and H, Two New Analogues of the Marine-Derived Quinone Sesquiterpene Penicilliumin A
title_short Myrothecols G and H, Two New Analogues of the Marine-Derived Quinone Sesquiterpene Penicilliumin A
title_sort myrothecols g and h, two new analogues of the marine-derived quinone sesquiterpene penicilliumin a
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483633/
https://www.ncbi.nlm.nih.gov/pubmed/26023841
http://dx.doi.org/10.3390/md13063360
work_keys_str_mv AT fuying myrothecolsgandhtwonewanaloguesofthemarinederivedquinonesesquiterpenepenicilliumina
AT wuping myrothecolsgandhtwonewanaloguesofthemarinederivedquinonesesquiterpenepenicilliumina
AT xuejinghua myrothecolsgandhtwonewanaloguesofthemarinederivedquinonesesquiterpenepenicilliumina
AT lihanxiang myrothecolsgandhtwonewanaloguesofthemarinederivedquinonesesquiterpenepenicilliumina
AT weixiaoyi myrothecolsgandhtwonewanaloguesofthemarinederivedquinonesesquiterpenepenicilliumina

Ejemplares similares