New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris

Two new cembranes, columnariols A (1) and B (2), were isolated from the cultured soft coral Nephthea columnaris. The structures of cembranes 1 and 2 were elucidated by spectroscopic methods. In the anti-inflammatory effects test, cembranes 1 and 2 were found to significantly inhibit the accumulation...

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Detalles Bibliográficos
Autores principales: Hsiao, Ting-Hsi, Sung, Chun-Sung, Lan, Yu-Hsuan, Wang, Yi-Chen, Lu, Mei-Chin, Wen, Zhi-Hong, Wu, Yang-Chang, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483638/
https://www.ncbi.nlm.nih.gov/pubmed/26035022
http://dx.doi.org/10.3390/md13063443
Descripción
Sumario:Two new cembranes, columnariols A (1) and B (2), were isolated from the cultured soft coral Nephthea columnaris. The structures of cembranes 1 and 2 were elucidated by spectroscopic methods. In the anti-inflammatory effects test, cembranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Compound 1 exhibited moderate cytotoxicity toward LNCaP cells with an IC(50) value of 9.80 μg/mL.

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