Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)

Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Ngokpol, Suthatip, Suwakulsiri, Wittaya, Sureram, Sanya, Lirdprapamongkol, Kriengsak, Aree, Thammarat, Wiyakrutta, Suthep, Mahidol, Chulabhorn, Ruchirawat, Somsak, Kittakoop, Prasat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483645/
https://www.ncbi.nlm.nih.gov/pubmed/26058010
http://dx.doi.org/10.3390/md13063567
_version_ 1782378589221552128
author Ngokpol, Suthatip
Suwakulsiri, Wittaya
Sureram, Sanya
Lirdprapamongkol, Kriengsak
Aree, Thammarat
Wiyakrutta, Suthep
Mahidol, Chulabhorn
Ruchirawat, Somsak
Kittakoop, Prasat
author_facet Ngokpol, Suthatip
Suwakulsiri, Wittaya
Sureram, Sanya
Lirdprapamongkol, Kriengsak
Aree, Thammarat
Wiyakrutta, Suthep
Mahidol, Chulabhorn
Ruchirawat, Somsak
Kittakoop, Prasat
author_sort Ngokpol, Suthatip
collection PubMed
description Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity.
format Online
Article
Text
id pubmed-4483645
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-44836452015-06-30 Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum) Ngokpol, Suthatip Suwakulsiri, Wittaya Sureram, Sanya Lirdprapamongkol, Kriengsak Aree, Thammarat Wiyakrutta, Suthep Mahidol, Chulabhorn Ruchirawat, Somsak Kittakoop, Prasat Mar Drugs Article Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity. MDPI 2015-06-05 /pmc/articles/PMC4483645/ /pubmed/26058010 http://dx.doi.org/10.3390/md13063567 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ngokpol, Suthatip
Suwakulsiri, Wittaya
Sureram, Sanya
Lirdprapamongkol, Kriengsak
Aree, Thammarat
Wiyakrutta, Suthep
Mahidol, Chulabhorn
Ruchirawat, Somsak
Kittakoop, Prasat
Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)
title Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)
title_full Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)
title_fullStr Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)
title_full_unstemmed Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)
title_short Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)
title_sort drimane sesquiterpene-conjugated amino acids from a marine isolate of the fungus talaromyces minioluteus (penicillium minioluteum)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483645/
https://www.ncbi.nlm.nih.gov/pubmed/26058010
http://dx.doi.org/10.3390/md13063567
work_keys_str_mv AT ngokpolsuthatip drimanesesquiterpeneconjugatedaminoacidsfromamarineisolateofthefungustalaromycesminioluteuspenicilliumminioluteum
AT suwakulsiriwittaya drimanesesquiterpeneconjugatedaminoacidsfromamarineisolateofthefungustalaromycesminioluteuspenicilliumminioluteum
AT sureramsanya drimanesesquiterpeneconjugatedaminoacidsfromamarineisolateofthefungustalaromycesminioluteuspenicilliumminioluteum
AT lirdprapamongkolkriengsak drimanesesquiterpeneconjugatedaminoacidsfromamarineisolateofthefungustalaromycesminioluteuspenicilliumminioluteum
AT areethammarat drimanesesquiterpeneconjugatedaminoacidsfromamarineisolateofthefungustalaromycesminioluteuspenicilliumminioluteum
AT wiyakruttasuthep drimanesesquiterpeneconjugatedaminoacidsfromamarineisolateofthefungustalaromycesminioluteuspenicilliumminioluteum
AT mahidolchulabhorn drimanesesquiterpeneconjugatedaminoacidsfromamarineisolateofthefungustalaromycesminioluteuspenicilliumminioluteum
AT ruchirawatsomsak drimanesesquiterpeneconjugatedaminoacidsfromamarineisolateofthefungustalaromycesminioluteuspenicilliumminioluteum
AT kittakoopprasat drimanesesquiterpeneconjugatedaminoacidsfromamarineisolateofthefungustalaromycesminioluteuspenicilliumminioluteum

Ejemplares similares