Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.

Four new iodobenzene-containing dipeptides (1–4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A–E (1–5) and...

Descripción completa

Detalles Bibliográficos
Autores principales: Won, Tae Hyung, Kim, Chang-Kwon, Lee, So-Hyoung, Rho, Boon Jo, Lee, Sang Kook, Oh, Dong-Chan, Oh, Ki-Bong, Shin, Jongheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483659/
https://www.ncbi.nlm.nih.gov/pubmed/26087023
http://dx.doi.org/10.3390/md13063836
Descripción
Sumario:Four new iodobenzene-containing dipeptides (1–4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A–E (1–5) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey’s analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na(+)/K(+)-ATPase (4).

Ejemplares similares