Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.

Four new iodobenzene-containing dipeptides (1–4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A–E (1–5) and...

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Autores principales: Won, Tae Hyung, Kim, Chang-Kwon, Lee, So-Hyoung, Rho, Boon Jo, Lee, Sang Kook, Oh, Dong-Chan, Oh, Ki-Bong, Shin, Jongheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483659/
https://www.ncbi.nlm.nih.gov/pubmed/26087023
http://dx.doi.org/10.3390/md13063836
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author Won, Tae Hyung
Kim, Chang-Kwon
Lee, So-Hyoung
Rho, Boon Jo
Lee, Sang Kook
Oh, Dong-Chan
Oh, Ki-Bong
Shin, Jongheon
author_facet Won, Tae Hyung
Kim, Chang-Kwon
Lee, So-Hyoung
Rho, Boon Jo
Lee, Sang Kook
Oh, Dong-Chan
Oh, Ki-Bong
Shin, Jongheon
author_sort Won, Tae Hyung
collection PubMed
description Four new iodobenzene-containing dipeptides (1–4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A–E (1–5) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey’s analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na(+)/K(+)-ATPase (4).
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spelling pubmed-44836592015-06-30 Amino Acid-Derived Metabolites from the Ascidian Aplidium sp. Won, Tae Hyung Kim, Chang-Kwon Lee, So-Hyoung Rho, Boon Jo Lee, Sang Kook Oh, Dong-Chan Oh, Ki-Bong Shin, Jongheon Mar Drugs Article Four new iodobenzene-containing dipeptides (1–4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A–E (1–5) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey’s analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na(+)/K(+)-ATPase (4). MDPI 2015-06-16 /pmc/articles/PMC4483659/ /pubmed/26087023 http://dx.doi.org/10.3390/md13063836 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Won, Tae Hyung
Kim, Chang-Kwon
Lee, So-Hyoung
Rho, Boon Jo
Lee, Sang Kook
Oh, Dong-Chan
Oh, Ki-Bong
Shin, Jongheon
Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.
title Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.
title_full Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.
title_fullStr Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.
title_full_unstemmed Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.
title_short Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.
title_sort amino acid-derived metabolites from the ascidian aplidium sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483659/
https://www.ncbi.nlm.nih.gov/pubmed/26087023
http://dx.doi.org/10.3390/md13063836
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