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Does Treatment Impact Health Outcomes for Patients After Acute Coronary Syndrome?

Background: Mortality rates for acute coronary syndrome (ACS) patients are still very high all over the world. Our study aimed to investigate the impact of ACS treatment on cardiovascular (CV) mortality eight years following ACS. Methods: A retrospective cohort study with a total of 613 patients was...

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Autores principales: Umbrasienė, Jelena, Vanagas, Giedrius, Venclovienė, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483692/
https://www.ncbi.nlm.nih.gov/pubmed/26035661
http://dx.doi.org/10.3390/ijerph120606136
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author Umbrasienė, Jelena
Vanagas, Giedrius
Venclovienė, Jon
author_facet Umbrasienė, Jelena
Vanagas, Giedrius
Venclovienė, Jon
author_sort Umbrasienė, Jelena
collection PubMed
description Background: Mortality rates for acute coronary syndrome (ACS) patients are still very high all over the world. Our study aimed to investigate the impact of ACS treatment on cardiovascular (CV) mortality eight years following ACS. Methods: A retrospective cohort study with a total of 613 patients was used. The data was collected from databases and medical records. An evidence-based treatment (EBT) algorithm was used based on the ESC guidelines. Logistic regression analysis and standardized odds ratios with 95% confidence interval (CI) were used for the risk assessment, with a p level < 0.05 considered as significant. Results: The median follow-up time in this study was 7.6 years. During follow-up 48.9% of the patients (n = 300) died from CV and 207 (69%) for a relevant reason. For monotherapy ACE inhibitors and β-blockers, and for fixed dose combined drugs ACE inhibitors and diuretics, were most frequently used. EBT was provided to 37.8% of patients. The EBT use (HR 0.541, CI 0.394–0.742, p < 0.001) during follow-up period was important for reducing CV mortality in ACS patients. Conclusions: The combined use of EBT significantly improved outcomes. The recurrent myocardial infarction and percutaneous coronary intervention patients were more frequent in EBT and it was beneficial for reducing CV mortality.
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spelling pubmed-44836922015-06-30 Does Treatment Impact Health Outcomes for Patients After Acute Coronary Syndrome? Umbrasienė, Jelena Vanagas, Giedrius Venclovienė, Jon Int J Environ Res Public Health Article Background: Mortality rates for acute coronary syndrome (ACS) patients are still very high all over the world. Our study aimed to investigate the impact of ACS treatment on cardiovascular (CV) mortality eight years following ACS. Methods: A retrospective cohort study with a total of 613 patients was used. The data was collected from databases and medical records. An evidence-based treatment (EBT) algorithm was used based on the ESC guidelines. Logistic regression analysis and standardized odds ratios with 95% confidence interval (CI) were used for the risk assessment, with a p level < 0.05 considered as significant. Results: The median follow-up time in this study was 7.6 years. During follow-up 48.9% of the patients (n = 300) died from CV and 207 (69%) for a relevant reason. For monotherapy ACE inhibitors and β-blockers, and for fixed dose combined drugs ACE inhibitors and diuretics, were most frequently used. EBT was provided to 37.8% of patients. The EBT use (HR 0.541, CI 0.394–0.742, p < 0.001) during follow-up period was important for reducing CV mortality in ACS patients. Conclusions: The combined use of EBT significantly improved outcomes. The recurrent myocardial infarction and percutaneous coronary intervention patients were more frequent in EBT and it was beneficial for reducing CV mortality. MDPI 2015-05-29 2015-06 /pmc/articles/PMC4483692/ /pubmed/26035661 http://dx.doi.org/10.3390/ijerph120606136 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Umbrasienė, Jelena
Vanagas, Giedrius
Venclovienė, Jon
Does Treatment Impact Health Outcomes for Patients After Acute Coronary Syndrome?
title Does Treatment Impact Health Outcomes for Patients After Acute Coronary Syndrome?
title_full Does Treatment Impact Health Outcomes for Patients After Acute Coronary Syndrome?
title_fullStr Does Treatment Impact Health Outcomes for Patients After Acute Coronary Syndrome?
title_full_unstemmed Does Treatment Impact Health Outcomes for Patients After Acute Coronary Syndrome?
title_short Does Treatment Impact Health Outcomes for Patients After Acute Coronary Syndrome?
title_sort does treatment impact health outcomes for patients after acute coronary syndrome?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483692/
https://www.ncbi.nlm.nih.gov/pubmed/26035661
http://dx.doi.org/10.3390/ijerph120606136
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