Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β

Abnormal tau hyperphosphorylation is an early pathological marker of Alzheimer’s disease (AD), however, the upstream factors that regulate tau phosphorylation are not illustrated and there is no efficient strategy to arrest tau hyperphosphorylation. Here, we find that activation of endogenous EphB2...

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Detalles Bibliográficos
Autores principales: Jiang, Jun, Wang, Zhi-Hao, Qu, Min, Gao, Di, Liu, Xiu-Ping, Zhu, Ling-Qiang, Wang, Jian-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484244/
https://www.ncbi.nlm.nih.gov/pubmed/26119563
http://dx.doi.org/10.1038/srep11765

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