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Dietary protein and lifespan across the metamorphic boundary: protein-restricted larvae develop into short-lived adults

Restriction of nutrients in the adult diet extends lifespan across a diverse range of species, but less is known about the long-term effects of developmental dietary restriction. In particular, it is not known whether adult lifespan is influenced by developmental caloric restriction or macronutrient...

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Autores principales: Runagall-McNaull, A., Bonduriansky, R., Crean, A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484247/
https://www.ncbi.nlm.nih.gov/pubmed/26119686
http://dx.doi.org/10.1038/srep11783
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author Runagall-McNaull, A.
Bonduriansky, R.
Crean, A. J.
author_facet Runagall-McNaull, A.
Bonduriansky, R.
Crean, A. J.
author_sort Runagall-McNaull, A.
collection PubMed
description Restriction of nutrients in the adult diet extends lifespan across a diverse range of species, but less is known about the long-term effects of developmental dietary restriction. In particular, it is not known whether adult lifespan is influenced by developmental caloric restriction or macronutrient balance. We used the nutritional geometry approach to independently manipulate protein and carbohydrate contents of the larval diet in the neriid fly, Telostylinus angusticollis, and measured adult lifespan. We found that adult male and female lifespan was shortest when larvae were fed a protein restricted diet. Thus, protein restriction in the larval diet has the opposite effect of protein restriction in the adult diet (which prolongs life in this species and across a wide range of taxa). Adult lifespan was unaffected by larval dietary carbohydrate. These patterns persisted after controlling for larval diet effects on adult body size. We propose that larval and adult protein sources are used for distinct metabolic tasks: during development, dietary protein is used to build a durable soma that enhances adult lifespan, although excessive protein consumption partially reverses this effect.
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spelling pubmed-44842472015-07-08 Dietary protein and lifespan across the metamorphic boundary: protein-restricted larvae develop into short-lived adults Runagall-McNaull, A. Bonduriansky, R. Crean, A. J. Sci Rep Article Restriction of nutrients in the adult diet extends lifespan across a diverse range of species, but less is known about the long-term effects of developmental dietary restriction. In particular, it is not known whether adult lifespan is influenced by developmental caloric restriction or macronutrient balance. We used the nutritional geometry approach to independently manipulate protein and carbohydrate contents of the larval diet in the neriid fly, Telostylinus angusticollis, and measured adult lifespan. We found that adult male and female lifespan was shortest when larvae were fed a protein restricted diet. Thus, protein restriction in the larval diet has the opposite effect of protein restriction in the adult diet (which prolongs life in this species and across a wide range of taxa). Adult lifespan was unaffected by larval dietary carbohydrate. These patterns persisted after controlling for larval diet effects on adult body size. We propose that larval and adult protein sources are used for distinct metabolic tasks: during development, dietary protein is used to build a durable soma that enhances adult lifespan, although excessive protein consumption partially reverses this effect. Nature Publishing Group 2015-06-29 /pmc/articles/PMC4484247/ /pubmed/26119686 http://dx.doi.org/10.1038/srep11783 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Runagall-McNaull, A.
Bonduriansky, R.
Crean, A. J.
Dietary protein and lifespan across the metamorphic boundary: protein-restricted larvae develop into short-lived adults
title Dietary protein and lifespan across the metamorphic boundary: protein-restricted larvae develop into short-lived adults
title_full Dietary protein and lifespan across the metamorphic boundary: protein-restricted larvae develop into short-lived adults
title_fullStr Dietary protein and lifespan across the metamorphic boundary: protein-restricted larvae develop into short-lived adults
title_full_unstemmed Dietary protein and lifespan across the metamorphic boundary: protein-restricted larvae develop into short-lived adults
title_short Dietary protein and lifespan across the metamorphic boundary: protein-restricted larvae develop into short-lived adults
title_sort dietary protein and lifespan across the metamorphic boundary: protein-restricted larvae develop into short-lived adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484247/
https://www.ncbi.nlm.nih.gov/pubmed/26119686
http://dx.doi.org/10.1038/srep11783
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