Mutations of c-Cbl in myeloid malignancies

Next generation sequencing has shown the frequent occurrence of point mutations in the ubiquitin E3 ligase c-Cbl in myeloid malignancies. Mouse models revealed a causal contribution of c-Cbl for the onset of such neoplasms. The point mutations typically cluster in the linker region and RING finger d...

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Detalles Bibliográficos
Autores principales: Katzav, Shulamit, Schmitz, M. Lienhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484412/
https://www.ncbi.nlm.nih.gov/pubmed/26028666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484412/
https://www.ncbi.nlm.nih.gov/pubmed/26028666

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