Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction

Caloric restriction (CR) was recently demonstrated by us to restrict ovarian cancer growth in vivo. CR resulted in activation of energy regulating enzymes adenosine monophosphate activated kinase (AMPK) and sirtuin 1 (SIRT1) followed by downstream inhibition of Akt-mTOR. In the present study, we inv...

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Detalles Bibliográficos
Autores principales: Al-Wahab, Zaid, Mert, Ismail, Tebbe, Calvin, Chhina, Jasdeep, Hijaz, Miriana, Morris, Robert T., Ali-Fehmi, Rouba, Giri, Shailendra, Munkarah, Adnan R., Rattan, Ramandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484428/
https://www.ncbi.nlm.nih.gov/pubmed/25895126

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