Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression

Pygopus-2 over-expression has been reported in several malignancies, such as ovarian, breast, lung and liver cancers. Here we demonstrated that down-regulation of Pygopus-2 by shRNA inhibited hepatic carcinoma cell invasion in vitro and metastasis in xenograft tumor models, which were promoted when...

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Autores principales: Zhang, Sheng, Li, Jie, Liu, Pingguo, Xu, Jianfeng, Zhao, Wenxiu, Xie, Chengrong, Yin, Zhenyu, Wang, Xiaomin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484440/
https://www.ncbi.nlm.nih.gov/pubmed/25871475
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author Zhang, Sheng
Li, Jie
Liu, Pingguo
Xu, Jianfeng
Zhao, Wenxiu
Xie, Chengrong
Yin, Zhenyu
Wang, Xiaomin
author_facet Zhang, Sheng
Li, Jie
Liu, Pingguo
Xu, Jianfeng
Zhao, Wenxiu
Xie, Chengrong
Yin, Zhenyu
Wang, Xiaomin
author_sort Zhang, Sheng
collection PubMed
description Pygopus-2 over-expression has been reported in several malignancies, such as ovarian, breast, lung and liver cancers. Here we demonstrated that down-regulation of Pygopus-2 by shRNA inhibited hepatic carcinoma cell invasion in vitro and metastasis in xenograft tumor models, which were promoted when Pygopus-2 was over-expressed. Pygopus-2 increased hepatic carcinoma cell invasion and metastasis, by decreasing E-cadherin. Pygopus-2 could bind to the E-cadherin promoter, increasing its methylation, and also indirectly decreased zeb2 expression. In turn these effects caused down-regulation of E-cadherin, potentiating invasion and metastasis. We suggest that targeting Pygopus-2 may potentially inhibit metastasis of hepatic carcinoma.
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spelling pubmed-44844402015-07-10 Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression Zhang, Sheng Li, Jie Liu, Pingguo Xu, Jianfeng Zhao, Wenxiu Xie, Chengrong Yin, Zhenyu Wang, Xiaomin Oncotarget Research Paper Pygopus-2 over-expression has been reported in several malignancies, such as ovarian, breast, lung and liver cancers. Here we demonstrated that down-regulation of Pygopus-2 by shRNA inhibited hepatic carcinoma cell invasion in vitro and metastasis in xenograft tumor models, which were promoted when Pygopus-2 was over-expressed. Pygopus-2 increased hepatic carcinoma cell invasion and metastasis, by decreasing E-cadherin. Pygopus-2 could bind to the E-cadherin promoter, increasing its methylation, and also indirectly decreased zeb2 expression. In turn these effects caused down-regulation of E-cadherin, potentiating invasion and metastasis. We suggest that targeting Pygopus-2 may potentially inhibit metastasis of hepatic carcinoma. Impact Journals LLC 2015-03-14 /pmc/articles/PMC4484440/ /pubmed/25871475 Text en Copyright: © 2015 Zhang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhang, Sheng
Li, Jie
Liu, Pingguo
Xu, Jianfeng
Zhao, Wenxiu
Xie, Chengrong
Yin, Zhenyu
Wang, Xiaomin
Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression
title Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression
title_full Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression
title_fullStr Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression
title_full_unstemmed Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression
title_short Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression
title_sort pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing e-cadherin expression
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484440/
https://www.ncbi.nlm.nih.gov/pubmed/25871475
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