Cargando…

FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway

The autocrine platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) signaling pathway promotes breast cancer tumorigenesis, but the mechanisms for its dysregulation in breast cancer are largely unknown. In the study, we identified PDGF-A as a novel transcriptional target of FoxM1. FoxM1 direct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Guanzhen, Zhou, Aidong, Xue, Jianfei, Huang, Chen, Zhang, Xia, Kang, Shin-Hyuk, Chiu, Wen-Tai, Tan, Christina, Xie, Keping, Wang, Jiejun, Huang, Suyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484456/ https://www.ncbi.nlm.nih.gov/pubmed/25869208

Ejemplares similares

PDGF and PDGF receptors in glioma
por: Nazarenko, Inga, et al.
Publicado: (2012)

Accumulation of PDGF B and cell-binding forms of PDGF A in the extracellular matrix
Publicado: (1993)

PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly
Publicado: (1992)

PDGF, NGF, and EGF as main contributors to tumorigenesis in high-risk retinoblastoma
por: Al-Ghazzawi, Karim, et al.
Publicado: (2023)

HGF/Met and FOXM1 Form a Positive Feedback Loop and Render Pancreatic Cancer Cells Resistance to Met Inhibition and Aggressive Phenotypes
por: Cui, Jiujie, et al.
Publicado: (2016)

Membrane-anchored form of v-sis/PDGF-B induces mitogenesis without detectable PDGF receptor autophosphorylation
Publicado: (1991)

Osteoclasts Control Osteoblast Chemotaxis via PDGF-BB/PDGF Receptor Beta Signaling
por: Sanchez-Fernandez, Maria Arantzazu, et al.
Publicado: (2008)

Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor
Publicado: (1991)

PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors
Publicado: (1994)

The role of PDGF in radiation oncology
por: Li, Minglun, et al.
Publicado: (2007)

Autocrine PDGF stimulation in malignancies
por: Heldin, Carl-Henrik
Publicado: (2012)

Rat Hippocampal Neural Stem Cell Modulation Using PDGF, VEGF, PDGF/VEGF, and BDNF
por: Pelegri, Neus Gomila, et al.
Publicado: (2019)

Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors
Publicado: (1996)

Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR) Axis as Target for Antitumor and Antiangiogenic Therapy
por: Raica, Marius, et al.
Publicado: (2010)

Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling
por: Winkler, Ethan A, et al.
Publicado: (2010)

Low plasma PDGF-BB levels are associated with estradiol in postmenopausal osteoporosis: PDGF-BB mediated by estradiol in women
por: Tang, Lanhua, et al.
Publicado: (2017)

Coexpression of Platelet‐derived Growth Factor (PDGF) A‐Chain and PDGF Receptor Genes in Human Gastric Carcinomas
por: Tsuda, Toshitaka, et al.
Publicado: (1989)

Aberrantly high activation of a FoxM1–STMN1 axis contributes to progression and tumorigenesis in FoxM1-driven cancers
por: Liu, Jun, et al.
Publicado: (2021)

PDGF-Rα gene expression predicts proliferation, but PDGF-A suppresses transdifferentiation of neonatal mouse lung myofibroblasts
por: Kimani, Patricia W, et al.
Publicado: (2009)

Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha
por: Kadrmas, Julie L., et al.
Publicado: (2020)

Preoperative Serum Levels of PDGF-AB, PDGF-BB, TGF-α, EGF and ANG-2 in the Diagnosis of Endometrial Cancer
por: Kozłowski, Mateusz, et al.
Publicado: (2023)

Avasimibe inhibits tumor growth by targeting FoxM1-AKR1C1 in osteosarcoma
por: Wang, Liang, et al.
Publicado: (2019)

Modulation of the transport of a lysosomal enzyme by PDGF
Publicado: (1990)

PDGF and intracellular signaling in the timing of oligodendrocyte differentiation
Publicado: (1989)

Targeting the PDGF signaling pathway in tumor treatment
por: Heldin, Carl-Henrik
Publicado: (2013)

PDGF/PDGFR effects in osteosarcoma and the “add-on” strategy
por: Xu, Jie, et al.
Publicado: (2018)

PDGF-B Is Required for Development of the Glymphatic System
por: Munk, Anne Sofie, et al.
Publicado: (2019)

Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling
Publicado: (1994)

A fibronectin peptide redirects PDGF-BB/PDGFR complexes to macropinocytosis-like internalization and augments PDGF-BB survival signals
por: Zhu, Jia, et al.
Publicado: (2013)

Serial measurements of serum PDGF-AA, PDGF-BB, FGF2, and VEGF in multiresistant ovarian cancer patients treated with bevacizumab
por: Madsen, Christine Vestergaard, et al.
Publicado: (2012)

FRET-based Visualization of PDGF Receptor Activation at Membrane Microdomains
por: Seong, Jihye, et al.
Publicado: (2017)

Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B
por: Ahn, Seok-Yong, et al.
Publicado: (2012)

A novel lncRNA PTTG3P/miR-132/212-3p/FoxM1 feedback loop facilitates tumorigenesis and metastasis of pancreatic cancer
por: Liu, Wenyu, et al.
Publicado: (2020)

Arterial smooth muscle cells express platelet-derived growth factor (PDGF) A chain mRNA, secrete a PDGF-like mitogen, and bind exogenous PDGF in a phenotype- and growth state-dependent manner
Publicado: (1988)

Extracellular matrix alters PDGF regulation of fibroblast integrins
Publicado: (1996)

PDGF induced microRNA alterations in cancer cells
por: Shao, Minghai, et al.
Publicado: (2011)

Rationale for targeting VEGF, FGF, and PDGF for the treatment of NSCLC
por: Ballas, Marc S, et al.
Publicado: (2011)

PDGF/VEGF signaling controls cell size in Drosophila
por: Sims, David, et al.
Publicado: (2009)

VEGF-independent angiogenic pathways induced by PDGF-C
por: Li, Xuri, et al.
Publicado: (2010)

Dynamin Inhibitors Impair Endocytosis and Mitogenic Signaling of PDGF
por: Sadowski, Łukasz, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ckphno2ci2aq1u05eak9a4ff9p