Cargando…

FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells

FTY720, Fingolimod, is a functional antagonist to the sphingosine-1-phoaphate (S1P) receptor and an inhibitor of sphingosine kinase 1. Here, we showed that a combination of FTY720 and TRAIL induced apoptosis in human renal, breast, and colon carcinoma cells. Most importantly, this combination had no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Woo, Seon Min, Seo, Bo Ram, Min, Kyoung-jin, Kwon, Taeg Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484480/ https://www.ncbi.nlm.nih.gov/pubmed/25843953

Ejemplares similares

YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-κB-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells
por: Woo, Seon Min, et al.
Publicado: (2016)

Eupafolin enhances TRAIL-mediated apoptosis through cathepsin S-induced down-regulation of Mcl-1 expression and AMPK-mediated Bim up-regulation in renal carcinoma Caki cells
por: Han, Min Ae, et al.
Publicado: (2016)

Magnolol Enhances the Therapeutic Effects of TRAIL through DR5 Upregulation and Downregulation of c-FLIP and Mcl-1 Proteins in Cancer Cells
por: Woo, Seon Min, et al.
Publicado: (2020)

Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells
por: Yun, Jeong Mi, et al.
Publicado: (2018)

Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells
por: Min, Kyoung-jin, et al.
Publicado: (2020)

Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
por: Kim, Seok, et al.
Publicado: (2018)

Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin
por: Woo, Seon Min, et al.
Publicado: (2017)

FTY720-derivatives do not induce FTY720-like lymphopenia
por: Segura-Ulate, Ismael, et al.
Publicado: (2017)

Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells
por: Han, Min Ae, et al.
Publicado: (2016)

BIX-01294 sensitizes renal cancer Caki cells to TRAIL-induced apoptosis through downregulation of survivin expression and upregulation of DR5 expression
por: Woo, Seon Min, et al.
Publicado: (2018)

FTY720 attenuates excitotoxicity and neuroinflammation
por: Cipriani, Raffaela, et al.
Publicado: (2015)

Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells
por: Jung, Kyong-Jin, et al.
Publicado: (2015)

Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation
por: Woo, Seon Min, et al.
Publicado: (2019)

Lucanthone, Autophagy Inhibitor, Enhances the Apoptotic Effects of TRAIL through miR-216a-5p-Mediated DR5 Upregulation and DUB3-Mediated Mcl-1 Downregulation
por: Yoon, Ji Yun, et al.
Publicado: (2021)

Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization
por: Wu, Kaixin, et al.
Publicado: (2021)

FTY-720 induces apoptosis in neuroblastoma via multiple signaling pathways
por: Lange, Ingo, et al.
Publicado: (2017)

New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth
por: Alshaker, Heba, et al.
Publicado: (2017)

Cepharanthine Enhances TRAIL-Mediated Apoptosis Through STAMBPL1-Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells
por: Shahriyar, Sk Abrar, et al.
Publicado: (2018)

Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells
por: Park, Eun Jung, et al.
Publicado: (2016)

Coordinate Involvement of Cell Cycle Arrest and Apoptosis Strengthen the Effect of FTY720
por: Nagahara, Yukitoshi, et al.
Publicado: (2001)

Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability
por: Seo, Bo Ram, et al.
Publicado: (2014)

The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod
por: Patmanathan, Sathya Narayanan, et al.
Publicado: (2015)

The emerging role of FTY720 (Fingolimod) in cancer treatment
por: White, Christopher, et al.
Publicado: (2016)

The coffee diterpene kahweol enhances sensitivity to sorafenib in human renal carcinoma Caki cells through down-regulation of Mcl-1 and c-FLIP expression
por: Min, Kyoung-Jin, et al.
Publicado: (2017)

Correction: Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability
por: Seo, Bo Ram, et al.
Publicado: (2016)

NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin
por: Seo, Seung Un, et al.
Publicado: (2017)

Altered Expression of Signaling Genes in Jurkat Cells upon FTY720 Induced Apoptosis
por: Wang, Fang, et al.
Publicado: (2010)

Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway
por: Shahriyar, Sk Abrar, et al.
Publicado: (2020)

Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy
por: Enoru, Julius O., et al.
Publicado: (2016)

Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells
por: Jeon, Mi-Yeon, et al.
Publicado: (2020)

FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury
por: Rousselle, Thomas V., et al.
Publicado: (2020)

Fingolimod (Gileyna, FTY720): Innovative treatment for multiple sclerosis
por: Pinki,, et al.
Publicado: (2011)

Antinociceptive activity of the S1P-receptor agonist FTY720
por: Coste, Ovidiu, et al.
Publicado: (2008)

Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma
por: Woo, Seon Min, et al.
Publicado: (2019)

FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism
por: Bai, Li-Yuan, et al.
Publicado: (2017)

Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP
por: Jeon, Mi-Yeon, et al.
Publicado: (2018)

E3 ubiquitin ligases and deubiquitinases as modulators of TRAIL-mediated extrinsic apoptotic signaling pathway
por: Woo, Seon Min, et al.
Publicado: (2019)

Fingolimod (FTY720): First approved oral therapy for multiple sclerosis
por: Sharma, Sushil, et al.
Publicado: (2011)

Lymphocyte Modulation with FTY720 Improves Hemorrhagic Shock Survival in Swine
por: Hawksworth, Jason S., et al.
Publicado: (2012)

FTY720 in multiple sclerosis: the emerging evidence of its therapeutic value
por: Thomson, Andrew
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_cpvo71r493dtlep4u2eupsrt9r