Cargando…

3-(2-Bromoethyl)-indole inhibits the growth of cancer cells and NF-κB activation

Indole-3-carbinol (I3C) and diindolylmethane (DIM), found in cruciferous vegetables, have chemopreventive and anticancer properties. In the present study, 14 substituted indoles were tested for activity against SW480 colon cancer cells. Among these, 3-(2-bromoethyl)-indole, named BEI-9, showed the g...

Descripción completa

Detalles Bibliográficos
Autores principales:	FADLALLA, KHALDA, ELGENDY, RAMY, GILBREATH, EBONY, PONDUGULA, SATYANARAYANA R, YEHUALAESHET, TESHOME, MANSOUR, MAHMOUD, SERBESSA, TESFAYE, MANNE, UPENDER, SAMUEL, TEMESGEN
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484612/ https://www.ncbi.nlm.nih.gov/pubmed/26063116 http://dx.doi.org/10.3892/or.2015.3970

Ejemplares similares

Variable NF-κB pathway responses in colon cancer cells treated with chemotherapeutic drugs
por: Samuel, Temesgen, et al.
Publicado: (2014)

N,N-Bis(2-bromoethyl)aniline
por: Bojan, R. Vilma, et al.
Publicado: (2007)

Bis(2-bromoethyl)ammonium bromide
por: Padayachy, Kamentheren, et al.
Publicado: (2012)

9-(2-Bromoethyl)-9H-carbazole
por: Zhao, Bao-Hua, et al.
Publicado: (2012)

2-(2-Bromoethyl)isoindoline-1,3-dione
por: Sun, Xiao-Qiang, et al.
Publicado: (2011)

rac-1-(2-Aminocarbonyl-2-bromoethyl)pyridinium bromide
por: Köppen, Robert, et al.
Publicado: (2012)

2-Bromoethyl 2-chloro-6-methylquinoline-3-carboxylate
por: Benzerka, Saida, et al.
Publicado: (2010)

The Combination of Omega-3 Stearidonic Acid and Docetaxel Enhances Cell Death over Docetaxel Alone in Human Prostate Cancer Cells
por: Mansour, Mahmoud, et al.
Publicado: (2018)

4-Bromo-5-[(2-bromoethyl)sulfanyl]-1,3-dithiole-2-thione
por: Ding, Jing-Jing, et al.
Publicado: (2009)

The Chemokine CXCL8 in Carcinogenesis and Drug Response
por: Gales, Dominique, et al.
Publicado: (2013)

3-(2-Bromoethyl)-5,5-diphenylimidazolidine-2,4-dione
por: Guerrab, Walid, et al.
Publicado: (2023)

Camptothecin Induces PD-L1 and Immunomodulatory Cytokines in Colon Cancer Cells
por: Bedi, Deepa, et al.
Publicado: (2019)

1-(2-Bromoethyl)-1,4-diazoniabicyclo[2.2.2]octane bromide tetrafluoroborate
por: Xiao, Jing-mei
Publicado: (2010)

Crystal and geometry-optimized structure, and Hirshfeld surface analysis of 1-(2-bromoethyl)indoline-2,3-dione
por: Sharmila, N., et al.
Publicado: (2016)

Influence of Metabolite Extraction Methods on (1)H-NMR-Based Metabolomic Profiling of Enteropathogenic Yersinia
por: Gines, Brandon R., et al.
Publicado: (2018)

Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol
por: Maltais, René, et al.
Publicado: (2011)

Ethyl 1-(2-bromoethyl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylate
por: Yin, Ling, et al.
Publicado: (2012)

Ion transport regulation by P2Y receptors, protein kinase C and phosphatidylinositol 3-kinase within the semicircular canal duct epithelium
por: Pondugula, Satyanarayana R, et al.
Publicado: (2010)

Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis
por: Zhuang, Huangming, et al.
Publicado: (2023)

1-(2-Bromoethyl)-1,4-diazoniabicyclo[2.2.2]octane bromide dihydrogen phosphate–phosphoric acid (1/1)
por: Xiao, Jing-Mei
Publicado: (2010)

Augmentation of Docetaxel-Induced Cytotoxicity in Human PC-3 Androgen-Independent Prostate Cancer Cells by Combination With Four Natural Apoptosis-Inducing Anticancer Compounds
por: Ahmed, Inass A, et al.
Publicado: (2023)

Nutritional assessment and associated factors in children with congenital heart disease—Ethiopia
por: Tsega, Temesgen, et al.
Publicado: (2022)

Prenatal programming: adverse cardiac programming by gestational testosterone excess
por: Vyas, Arpita K., et al.
Publicado: (2016)

Vulnerability to HIV infection among the Borana pastoral community of Southern Ethiopia: a persisting challenge
por: Serbessa, Mirgissa Kaba
Publicado: (2019)

Stimulatory Effect of Indolic Hormone on As(2)O(3) Cytotoxicity in Breast Cancer Cells: NF-κB-dependent Mechanism of Action of Melatonin
por: Safaroghli- Azar, Ava, et al.
Publicado: (2018)

Advances in pancreatic cancer biomarkers
por: Hasan, Syed, et al.
Publicado: (2019)

Comparative transcriptome analyses reveal genes associated with SARS-CoV-2 infection of human lung epithelial cells
por: Chandrashekar, Darshan S., et al.
Publicado: (2021)

Elevated Protein Kinase A Activity in Stomach Mesenchyme Disrupts Mesenchymal-epithelial Crosstalk and Induces Preneoplasia
por: Puri, Pawan, et al.
Publicado: (2022)

Sodium selectivity of semicircular canal duct epithelial cells
por: Yamazaki, Muneharu, et al.
Publicado: (2011)

Effects of Autologous Conditioned Serum, Autologous Protein Solution, and Triamcinolone on Inflammatory and Catabolic Gene Expression in Equine Cartilage and Synovial Explants Treated With IL-1β in Co-culture
por: Velloso Alvarez, Ana, et al.
Publicado: (2020)

NF-κB and Disease
por: Poma, Paola
Publicado: (2020)

Interplay between the Cannabinoid System and microRNAs in Cancer
por: Salamat, Julia M., et al.
Publicado: (2022)

NF-κB and the Immunoglobulin κ Gene Enhancer
por: Sen, Ranjan
Publicado: (2004)

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer
por: Colomer, Carlota, et al.
Publicado: (2017)

Quinic acid ameliorates ulcerative colitis in rats, through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways
por: Ghasemi‐Dehnoo, Maryam, et al.
Publicado: (2023)

Exploration of over the counter sales of antibiotics in community pharmacies of Addis Ababa, Ethiopia: pharmacy professionals’ perspective
por: Gebretekle, Gebremedhin Beedemariam, et al.
Publicado: (2016)

Indole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway
por: Xu, Xiaohong, et al.
Publicado: (2019)

Microbial metabolites indole derivatives sensitize mice to D-GalN/LPS induced-acute liver failure via the Tlr2/NF-κB pathway
por: Zhou, Ziyuan, et al.
Publicado: (2023)

Nef-M1, a CXCR4 Peptide Antagonist, Enhances Apoptosis and Inhibits Primary Tumor Growth and Metastasis in Breast Cancer
por: Bumpers, Harvey, et al.
Publicado: (2013)

Cirrhotomimetic hepatocellular carcinoma: experience of a single institution and review of the literature
por: Xiong, Meng-Jun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_e4lf5u7ciavkc46ib5t2vc8pp7