Cargando…

Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice

Fibroblast growth factor 21 (FGF21) is an important regulator in glucose and lipid metabolism, and has been considered as a potential therapy for diabetes. The effect of FGF21 on the development and progression of diabetes-induced pathogenic changes in the aorta has not currently been addressed. To...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Xiaoqing, Chen, Jun, Zhang, Chi, Zeng, Jun, Zhou, Shanshan, Zhang, Zhiguo, Lu, Xuemian, Chen, Jing, Feng, Wenke, Li, Xiaokun, Tan, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484638/ https://www.ncbi.nlm.nih.gov/pubmed/27391008 http://dx.doi.org/10.1186/s12933-015-0241-0

Ejemplares similares

FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation
por: Yan, Xiaoqing, et al.
Publicado: (2015)

Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart
por: Yang, Hong, et al.
Publicado: (2018)

Therapeutic Effects of Fibroblast Growth Factor-21 on Diabetic Nephropathy and the Possible Mechanism in Type 1 Diabetes Mellitus Mice
por: Weng, Wenya, et al.
Publicado: (2020)

Attenuation of Hyperlipidemia- and Diabetes-Induced Early-Stage Apoptosis and Late-Stage Renal Dysfunction via Administration of Fibroblast Growth Factor-21 Is Associated with Suppression of Renal Inflammation
por: Zhang, Chi, et al.
Publicado: (2013)

Serum fibroblast growth factor 21 levels is associated with lower extremity atherosclerotic disease in Chinese female diabetic patients
por: Zhang, Xiaoyan, et al.
Publicado: (2015)

Fibroblast growth factor 21 inhibition aggravates cardiac dysfunction in diabetic cardiomyopathy by improving lipid accumulation
por: Chen, Cui, et al.
Publicado: (2018)

Deletion of GIT1 Impacts eNOS Activity To Aggravate sFlt-1–Induced Preeclampsia Phenotype in Mice
por: Zhang, Shenghong, et al.
Publicado: (2018)

Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases
por: Cheng, Peng, et al.
Publicado: (2016)

Serum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes
por: Xiao, Yang, et al.
Publicado: (2015)

The Prevention of Diabetic Cardiomyopathy by Non-Mitogenic Acidic Fibroblast Growth Factor Is Probably Mediated by the Suppression of Oxidative Stress and Damage
por: Zhang, Chi, et al.
Publicado: (2013)

Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKα signaling pathway
por: Ying, Lei, et al.
Publicado: (2019)

Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women
por: Mascarenhas-Melo, Filipa, et al.
Publicado: (2013)

Diabetes-Induced Hepatic Pathogenic Damage, Inflammation, Oxidative Stress, and Insulin Resistance Was Exacerbated in Zinc Deficient Mouse Model
por: Zhang, Chi, et al.
Publicado: (2012)

The role of FGF21 in type 1 diabetes and its complications
por: Zhang, Jian, et al.
Publicado: (2018)

Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT
por: Lin, Sundong, et al.
Publicado: (2020)

Zinc protects against diabetes-induced pathogenic changes in the aorta: roles of metallothionein and nuclear factor (erythroid-derived 2)-like 2
por: Miao, Xiao, et al.
Publicado: (2013)

Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice
por: Ramirez-Hernandez, Gabriela, et al.
Publicado: (2021)

Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta
por: Cicek, Figen Amber, et al.
Publicado: (2013)

MiR-21-3p Inhibits Adipose Browning by Targeting FGFR1 and Aggravates Atrial Fibrosis in Diabetes
por: Pan, Jian-an, et al.
Publicado: (2021)

Intense exercise training is not effective to restore the endothelial NO-dependent relaxation in STZ-diabetic rat aorta
por: Zguira, Mohamed Sami, et al.
Publicado: (2013)

Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats
por: Guo, Zhixin, et al.
Publicado: (2012)

Aggravation of functional mitral regurgitation on left ventricle stiffness in type 2 diabetes mellitus patients evaluated by CMR tissue tracking
por: Zhang, Yi, et al.
Publicado: (2021)

Deletion of Metallothionein Exacerbates Intermittent Hypoxia-Induced Oxidative and Inflammatory Injury in Aorta
por: Zhou, Shanshan, et al.
Publicado: (2014)

Chromosome 9p21.3 polymorphism in a Chinese Han population is associated with angiographic coronary plaque progression in non-diabetic but not in type 2 diabetic patients
por: Wang, Wei, et al.
Publicado: (2010)

Fibroblast growth factor-23 is associated with imaging markers of diabetic cardiomyopathy and anti-diabetic therapeutics
por: Sørensen, Martin H., et al.
Publicado: (2020)

Generating Stable Knockout Zebrafish Lines by Deleting Large Chromosomal Fragments Using Multiple gRNAs
por: Kim, Brian H., et al.
Publicado: (2020)

A Better Anti-Diabetic Recombinant Human Fibroblast Growth Factor 21 (rhFGF21) Modified with Polyethylene Glycol
por: Huang, Zhifeng, et al.
Publicado: (2011)

MiR-21 protected against diabetic cardiomyopathy induced diastolic dysfunction by targeting gelsolin
por: Dai, Beibei, et al.
Publicado: (2018)

Construction of a Recyclable Genetic Marker and Serial Gene Deletions in the Human Pathogenic Mucorales Mucor circinelloides
por: Garcia, Alexis, et al.
Publicado: (2017)

Effects of Nigella sativa L. seed oil on intima–media thickness and Bax and Caspase 3 expression in diabetic rat aorta
por: Cüce, Gökhan, et al.
Publicado: (2016)

Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats
por: Failli, Paola, et al.
Publicado: (2009)

Different molecular mechanisms causing 9p21 deletions in acute lymphoblastic leukemia of childhood
por: Novara, Francesca, et al.
Publicado: (2009)

Deficiency of fibroblast growth factor 21 aggravates obesity-induced atrophic responses in skeletal muscle
por: Kim, Chu-Sook, et al.
Publicado: (2019)

Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury
por: Liu, Yanlong, et al.
Publicado: (2016)

Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice
por: Zhao, Cuiqing, et al.
Publicado: (2019)

A Population of Deletion Mutants and an Integrated Mapping and Exome-seq Pipeline for Gene Discovery in Maize
por: Jia, Shangang, et al.
Publicado: (2016)

ROCK1 Induces Endothelial-to-Mesenchymal Transition in Glomeruli to Aggravate Albuminuria in Diabetic Nephropathy
por: Peng, Hui, et al.
Publicado: (2016)

Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease
por: Shen, Yun, et al.
Publicado: (2013)

Fibroblast Growth Factor 21 in Gestational Diabetes Mellitus and Type 2 Diabetes Mellitus
por: Gawlik, Katarzyna, et al.
Publicado: (2023)

Mitochondrial DNA with a Large-Scale Deletion Causes Two Distinct Mitochondrial Disease Phenotypes in Mice
por: Katada, Shun, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ojn7bqspm1p8um1bi5bsp42ia8