Cargando…

Neutralization of the CD95 ligand by APG101 inhibits invasion of glioma cells in vitro

Glioblastoma is a disease characterized by rapid invasive tumour growth. Studies on the proapoptotic CD95/CD95L signalling pathway recently suggested a significant contribution of CD95 signalling towards the high degree of motility in glioma cells. Apogenix has developed APG101, a clinical phase II...

Descripción completa

Detalles Bibliográficos
Autores principales:	Merz, Christian, Strecker, Alexander, Sykora, Jaromir, Hill, Oliver, Fricke, Harald, Angel, Peter, Gieffers, Christian, Peterziel, Heike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2015
Materias:	Preclinical Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484665/ https://www.ncbi.nlm.nih.gov/pubmed/25850884 http://dx.doi.org/10.1097/CAD.0000000000000237

Ejemplares similares

The novel TRAIL-receptor agonist APG350 exerts superior therapeutic activity in pancreatic cancer cells
por: Legler, Karen, et al.
Publicado: (2018)

APG101 efficiently rescues erythropoiesis in lower risk myelodysplastic syndromes with severe impairment of hematopoiesis
por: Raimbault, Anna, et al.
Publicado: (2016)

CD95L and Anti-Tumor Immune Response: Current Understanding and New Evidence
por: Richards, David M, et al.
Publicado: (2021)

A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity
por: Thiemann, Meinolf, et al.
Publicado: (2018)

HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality
por: Richards, David M., et al.
Publicado: (2019)

HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer
por: Lipton, Allan, et al.
Publicado: (2013)

Poly-guanidine shows high cytotoxicity in glioma cell cultures and glioma stem cells
por: Márquez, Marcela, et al.
Publicado: (2022)

Podoplanin Positive Myeloid Cells Promote Glioma Development by Immune Suppression
por: Eisemann, Tanja, et al.
Publicado: (2019)

Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C
por: Vita, Marina F., et al.
Publicado: (2010)

Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted gliomas
por: Ruban, Angela, et al.
Publicado: (2012)

MicroRNA-195 reverses the resistance to temozolomide through targeting cyclin E1 in glioma cells
por: Wang, Hongqin, et al.
Publicado: (2019)

An advanced glioma cell invasion assay based on organotypic brain slice cultures
por: Eisemann, Tanja, et al.
Publicado: (2018)

Concepts for agonistic targeting of CD40 in immuno-oncology
por: Richards, David M., et al.
Publicado: (2019)

Copper (II) complexes of bidentate ligands exhibit potent anti-cancer activity regardless of platinum sensitivity status
por: Wehbe, Mohamed, et al.
Publicado: (2017)

Clinical Response to the CD95-Ligand Inhibitor Asunercept Is Defined by a Pro-Inflammatory Serum Cytokine Profile
por: Radujkovic, Aleksandar, et al.
Publicado: (2020)

Australian Parkinson’s Genetics Study (APGS): pilot (n=1532)
por: Bivol, Svetlana, et al.
Publicado: (2022)

The CD40 agonist HERA-CD40L results in enhanced activation of antigen presenting cells, promoting an anti-tumor effect alone and in combination with radiotherapy
por: Frankish, Jamie, et al.
Publicado: (2023)

Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway
por: Zhou, Jiabin, et al.
Publicado: (2019)

A novel ligand of the translationally controlled tumor protein (TCTP) identified by virtual drug screening for cancer differentiation therapy
por: Fischer, Nicolas, et al.
Publicado: (2021)

C–X–C ligand 10 and C–X–C receptor 3 status can predict tamoxifen treatment response in breast cancer patients
por: Hilborn, Erik, et al.
Publicado: (2014)

The role of CD95 and CD95 ligand in cancer
por: Peter, M E, et al.
Publicado: (2015)

Cardiac GRK2 and the Communicative Axis Between Heart and Fat
por: Hill, Bradford G.
Publicado: (2022)

CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma
por: Teodorczyk, M, et al.
Publicado: (2015)

MODL-01. Targeting replication stress in pediatric brain tumors
por: Krausert, Sonja, et al.
Publicado: (2022)

Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex
por: Kamada, Yoshiaki, et al.
Publicado: (2000)

Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast
por: Kirisako, Takayoshi, et al.
Publicado: (1999)

Integrative prognostic analysis of tumor–infiltrating lymphocytes, CD8, CD20, programmed cell death-ligand 1, and tertiary lymphoid structures in patients with early-stage triple-negative breast cancer who did not receive adjuvant chemotherapy
por: Yazaki, Shu, et al.
Publicado: (2022)

Abstract 25 Cord Blood Mononuclear Cells and Cord Blood Plasma Alter Human Cardiac Endothelial Cell Angiogenic Sprouting and Growth In Vitro
por: Chuang, Angela, et al.
Publicado: (2023)

Limitations of Sulforhodamine 101 for Brain Imaging
por: Hülsmann, Swen, et al.
Publicado: (2017)

Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors
por: Yeh, Elizabeth S., et al.
Publicado: (2014)

Co-expressed genes enhance precision of receptor status identification in breast cancer patients
por: Kenn, Michael, et al.
Publicado: (2018)

Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
por: Mizushima, Noboru, et al.
Publicado: (2001)

Regulation of tight junction assembly and epithelial morphogenesis by the heat shock protein Apg-2
por: Aijaz, Saima, et al.
Publicado: (2007)

The SMAC Mimetic APG-1387 Sensitizes Immune-Mediated Cell Apoptosis in Hepatocellular Carcinoma
por: Chen, Zide, et al.
Publicado: (2018)

Wetting Mechanism and Experimental Study of Synergistic Wetting of Bituminous Coal with SDS and APG1214
por: Sun, Liying, et al.
Publicado: (2021)

Homoharringtonine is synergistically lethal with BCL-2 inhibitor APG-2575 in acute myeloid leukemia
por: Wei, Wenwen, et al.
Publicado: (2022)

Influence of loading and grafting on hard‐ and soft‐tissue healing at immediately placed implants: An experimental study in minipigs
por: Parvini, Puria, et al.
Publicado: (2022)

MODL-04. Drug screening in Disorders with Abnormal DNA Damage Response/Repair (DADDR) andin vivo validation
por: Kolodziejczak, Anna, et al.
Publicado: (2022)

The estrogen receptor coactivator AIB1 is a new putative prognostic biomarker in ER-positive/HER2-negative invasive lobular carcinoma of the breast
por: Narbe, Ulrik, et al.
Publicado: (2019)

CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells
por: Drachsler, M, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2up9m3rc3kajkuha7abrq8dvlu