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APOE and LDLR Gene Polymorphisms and Dyslipidemia Tracking. Rio de Janeiro Study

BACKGROUND: Studies show an association between changes in apolipoprotein E (ApoE) and LDLR receptor with the occurrence of dyslipidemia. OBJECTIVES: To investigate the association between polymorphisms of the APOE (ε2, ε3, ε4) and LDLR (A370T) genes with the persistence of abnormal serum lipid leve...

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Autores principales: de Freitas, Rossana Ghessa Andrade, Campana, Erika Maria Gonçalves, Pozzan, Roberto, Brandão, Andréa Araujo, Brandão, Ayrton Pires, Magalhães, Maria Eliane Campos, da Silva, Dayse Aparecida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cardiologia 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484679/
https://www.ncbi.nlm.nih.gov/pubmed/26131702
http://dx.doi.org/10.5935/abc.20150036
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author de Freitas, Rossana Ghessa Andrade
Campana, Erika Maria Gonçalves
Pozzan, Roberto
Brandão, Andréa Araujo
Brandão, Ayrton Pires
Magalhães, Maria Eliane Campos
da Silva, Dayse Aparecida
author_facet de Freitas, Rossana Ghessa Andrade
Campana, Erika Maria Gonçalves
Pozzan, Roberto
Brandão, Andréa Araujo
Brandão, Ayrton Pires
Magalhães, Maria Eliane Campos
da Silva, Dayse Aparecida
author_sort de Freitas, Rossana Ghessa Andrade
collection PubMed
description BACKGROUND: Studies show an association between changes in apolipoprotein E (ApoE) and LDLR receptor with the occurrence of dyslipidemia. OBJECTIVES: To investigate the association between polymorphisms of the APOE (ε2, ε3, ε4) and LDLR (A370T) genes with the persistence of abnormal serum lipid levels in young individuals followed up for 17 years in the Rio de Janeiro Study. METHODS: The study included 56 individuals (35 males) who underwent three assessments at different ages: A1 (mean age 13.30 ± 1.53 years), A2 (22.09 ± 1.91 years) and A3 (31.23 ± 1.99 years). Clinical evaluation with measurement of blood pressure (BP) and body mass index (BMI) was conducted at all three assessments. Measurement of waist circumference (WC) and serum lipids, and analysis of genetic polymorphisms by PCR-RFLP were performed at A2 and A3. Based on dyslipidemia tracking, three groups were established: 0 (no abnormal lipid value at A2 and A3), 1 (up to one abnormal lipid value at A2 or A3) and 2 (one or more abnormal lipid values at A2 and A3). RESULTS: Compared with groups 0 and 1, group 2 presented higher mean values of BP, BMI, WC, LDL-c and TG (p < 0.01) and lower mean values of HDL-c (p = 0.001). Across the assessments, all individuals with APOE genotypes ε2/ε4 and ε4/ε4 maintained at least one abnormal lipid variable, whereas those with genotype ε2/ε3 did not show abnormal values (χ2 = 16.848, p = 0.032). For the LDLR genotypes, there was no significant difference among the groups. CONCLUSIONS: APOE gene polymorphisms were associated with dyslipidemia in young individuals followed up longitudinally from childhood.
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spelling pubmed-44846792015-07-01 APOE and LDLR Gene Polymorphisms and Dyslipidemia Tracking. Rio de Janeiro Study de Freitas, Rossana Ghessa Andrade Campana, Erika Maria Gonçalves Pozzan, Roberto Brandão, Andréa Araujo Brandão, Ayrton Pires Magalhães, Maria Eliane Campos da Silva, Dayse Aparecida Arq Bras Cardiol Original Article BACKGROUND: Studies show an association between changes in apolipoprotein E (ApoE) and LDLR receptor with the occurrence of dyslipidemia. OBJECTIVES: To investigate the association between polymorphisms of the APOE (ε2, ε3, ε4) and LDLR (A370T) genes with the persistence of abnormal serum lipid levels in young individuals followed up for 17 years in the Rio de Janeiro Study. METHODS: The study included 56 individuals (35 males) who underwent three assessments at different ages: A1 (mean age 13.30 ± 1.53 years), A2 (22.09 ± 1.91 years) and A3 (31.23 ± 1.99 years). Clinical evaluation with measurement of blood pressure (BP) and body mass index (BMI) was conducted at all three assessments. Measurement of waist circumference (WC) and serum lipids, and analysis of genetic polymorphisms by PCR-RFLP were performed at A2 and A3. Based on dyslipidemia tracking, three groups were established: 0 (no abnormal lipid value at A2 and A3), 1 (up to one abnormal lipid value at A2 or A3) and 2 (one or more abnormal lipid values at A2 and A3). RESULTS: Compared with groups 0 and 1, group 2 presented higher mean values of BP, BMI, WC, LDL-c and TG (p < 0.01) and lower mean values of HDL-c (p = 0.001). Across the assessments, all individuals with APOE genotypes ε2/ε4 and ε4/ε4 maintained at least one abnormal lipid variable, whereas those with genotype ε2/ε3 did not show abnormal values (χ2 = 16.848, p = 0.032). For the LDLR genotypes, there was no significant difference among the groups. CONCLUSIONS: APOE gene polymorphisms were associated with dyslipidemia in young individuals followed up longitudinally from childhood. Sociedade Brasileira de Cardiologia 2015-06 /pmc/articles/PMC4484679/ /pubmed/26131702 http://dx.doi.org/10.5935/abc.20150036 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
de Freitas, Rossana Ghessa Andrade
Campana, Erika Maria Gonçalves
Pozzan, Roberto
Brandão, Andréa Araujo
Brandão, Ayrton Pires
Magalhães, Maria Eliane Campos
da Silva, Dayse Aparecida
APOE and LDLR Gene Polymorphisms and Dyslipidemia Tracking. Rio de Janeiro Study
title APOE and LDLR Gene Polymorphisms and Dyslipidemia Tracking. Rio de Janeiro Study
title_full APOE and LDLR Gene Polymorphisms and Dyslipidemia Tracking. Rio de Janeiro Study
title_fullStr APOE and LDLR Gene Polymorphisms and Dyslipidemia Tracking. Rio de Janeiro Study
title_full_unstemmed APOE and LDLR Gene Polymorphisms and Dyslipidemia Tracking. Rio de Janeiro Study
title_short APOE and LDLR Gene Polymorphisms and Dyslipidemia Tracking. Rio de Janeiro Study
title_sort apoe and ldlr gene polymorphisms and dyslipidemia tracking. rio de janeiro study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484679/
https://www.ncbi.nlm.nih.gov/pubmed/26131702
http://dx.doi.org/10.5935/abc.20150036
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