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Common germline polymorphisms associated with breast cancer-specific survival

INTRODUCTION: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-sp...

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Autores principales: Pirie, Ailith, Guo, Qi, Kraft, Peter, Canisius, Sander, Eccles, Diana M, Rahman, Nazneen, Nevanlinna, Heli, Chen, Constance, Khan, Sofia, Tyrer, Jonathan, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Lush, Michael, Dunning, Alison M, Shah, Mitul, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Lambrechts, Dieter, Weltens, Caroline, Leunen, Karin, van Ongeval, Chantal, Nordestgaard, Børge G, Nielsen, Sune F, Flyger, Henrik, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Blomqvist, Carl, Aittomäki, Kristiina, Fagerholm, Rainer, Muranen, Taru A, Olsen, Janet E, Hallberg, Emily, Vachon, Celine, Knight, Julia A, Glendon, Gord, Mulligan, Anna Marie, Broeks, Annegien, Cornelissen, Sten, Haiman, Christopher A, Henderson, Brian E, Schumacher, Frederick, Le Marchand, Loic, Hopper, John L, Tsimiklis, Helen, Apicella, Carmel, Southey, Melissa C, Cross, Simon S, Reed, Malcolm WR, Giles, Graham G, Milne, Roger L, McLean, Catriona, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Hooning, Maartje J, Hollestelle, Antoinette, Martens, John WM, van den Ouweland, Ans MW, Marme, Federick, Schneeweiss, Andreas, Yang, Rongxi, Burwinkel, Barbara, Figueroa, Jonine, Chanock, Stephen J, Lissowska, Jolanta, Sawyer, Elinor J, Tomlinson, Ian, Kerin, Michael J, Miller, Nicola, Brenner, Hermann, Butterbach, Katja, Holleczek, Bernd, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Li, Jingmei, Brand, Judith S, Humphreys, Keith, Devilee, Peter, Tollenaar, Robert AEM, Seynaeve, Caroline, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Ficarazzi, Filomena, Beckmann, Matthias W, Hein, Alexander, Ekici, Arif B, Balleine, Rosemary, Phillips, Kelly-Anne, Benitez, Javier, Zamora, M Pilar, Perez, Jose Ignacio Arias, Menéndez, Primitiva, Jakubowska, Anna, Lubinski, Jan, Gronwald, Jacek, Durda, Katarzyna, Hamann, Ute, Kabisch, Maria, Ulmer, Hans Ulrich, Rüdiger, Thomas, Margolin, Sara, Kristensen, Vessela, Nord, Siljie, Evans, D Gareth, Abraham, Jean, Earl, Helena, Poole, Christopher J, Hiller, Louise, Dunn, Janet A, Bowden, Sarah, Yang, Rose, Campa, Daniele, Diver, W Ryan, Gapstur, Susan M, Gaudet, Mia M, Hankinson, Susan, Hoover, Robert N, Hüsing, Anika, Kaaks, Rudolf, Machiela, Mitchell J, Willett, Walter, Barrdahl, Myrto, Canzian, Federico, Chin, Suet-Feung, Caldas, Carlos, Hunter, David J, Lindstrom, Sara, Garcia-Closas, Montserrat, Couch, Fergus J, Chenevix-Trench, Georgia, Mannermaa, Arto, Andrulis, Irene L, Hall, Per, Chang-Claude, Jenny, Easton, Douglas F, Bojesen, Stig E, Cox, Angela, Fasching, Peter A, Pharoah, Paul DP, Schmidt, Marjanka K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484708/
https://www.ncbi.nlm.nih.gov/pubmed/25897948
http://dx.doi.org/10.1186/s13058-015-0570-7
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author Pirie, Ailith
Guo, Qi
Kraft, Peter
Canisius, Sander
Eccles, Diana M
Rahman, Nazneen
Nevanlinna, Heli
Chen, Constance
Khan, Sofia
Tyrer, Jonathan
Bolla, Manjeet K
Wang, Qin
Dennis, Joe
Michailidou, Kyriaki
Lush, Michael
Dunning, Alison M
Shah, Mitul
Czene, Kamila
Darabi, Hatef
Eriksson, Mikael
Lambrechts, Dieter
Weltens, Caroline
Leunen, Karin
van Ongeval, Chantal
Nordestgaard, Børge G
Nielsen, Sune F
Flyger, Henrik
Rudolph, Anja
Seibold, Petra
Flesch-Janys, Dieter
Blomqvist, Carl
Aittomäki, Kristiina
Fagerholm, Rainer
Muranen, Taru A
Olsen, Janet E
Hallberg, Emily
Vachon, Celine
Knight, Julia A
Glendon, Gord
Mulligan, Anna Marie
Broeks, Annegien
Cornelissen, Sten
Haiman, Christopher A
Henderson, Brian E
Schumacher, Frederick
Le Marchand, Loic
Hopper, John L
Tsimiklis, Helen
Apicella, Carmel
Southey, Melissa C
Cross, Simon S
Reed, Malcolm WR
Giles, Graham G
Milne, Roger L
McLean, Catriona
Winqvist, Robert
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Hooning, Maartje J
Hollestelle, Antoinette
Martens, John WM
van den Ouweland, Ans MW
Marme, Federick
Schneeweiss, Andreas
Yang, Rongxi
Burwinkel, Barbara
Figueroa, Jonine
Chanock, Stephen J
Lissowska, Jolanta
Sawyer, Elinor J
Tomlinson, Ian
Kerin, Michael J
Miller, Nicola
Brenner, Hermann
Butterbach, Katja
Holleczek, Bernd
Kataja, Vesa
Kosma, Veli-Matti
Hartikainen, Jaana M
Li, Jingmei
Brand, Judith S
Humphreys, Keith
Devilee, Peter
Tollenaar, Robert AEM
Seynaeve, Caroline
Radice, Paolo
Peterlongo, Paolo
Manoukian, Siranoush
Ficarazzi, Filomena
Beckmann, Matthias W
Hein, Alexander
Ekici, Arif B
Balleine, Rosemary
Phillips, Kelly-Anne
Benitez, Javier
Zamora, M Pilar
Perez, Jose Ignacio Arias
Menéndez, Primitiva
Jakubowska, Anna
Lubinski, Jan
Gronwald, Jacek
Durda, Katarzyna
Hamann, Ute
Kabisch, Maria
Ulmer, Hans Ulrich
Rüdiger, Thomas
Margolin, Sara
Kristensen, Vessela
Nord, Siljie
Evans, D Gareth
Abraham, Jean
Earl, Helena
Poole, Christopher J
Hiller, Louise
Dunn, Janet A
Bowden, Sarah
Yang, Rose
Campa, Daniele
Diver, W Ryan
Gapstur, Susan M
Gaudet, Mia M
Hankinson, Susan
Hoover, Robert N
Hüsing, Anika
Kaaks, Rudolf
Machiela, Mitchell J
Willett, Walter
Barrdahl, Myrto
Canzian, Federico
Chin, Suet-Feung
Caldas, Carlos
Hunter, David J
Lindstrom, Sara
Garcia-Closas, Montserrat
Couch, Fergus J
Chenevix-Trench, Georgia
Mannermaa, Arto
Andrulis, Irene L
Hall, Per
Chang-Claude, Jenny
Easton, Douglas F
Bojesen, Stig E
Cox, Angela
Fasching, Peter A
Pharoah, Paul DP
Schmidt, Marjanka K
author_facet Pirie, Ailith
Guo, Qi
Kraft, Peter
Canisius, Sander
Eccles, Diana M
Rahman, Nazneen
Nevanlinna, Heli
Chen, Constance
Khan, Sofia
Tyrer, Jonathan
Bolla, Manjeet K
Wang, Qin
Dennis, Joe
Michailidou, Kyriaki
Lush, Michael
Dunning, Alison M
Shah, Mitul
Czene, Kamila
Darabi, Hatef
Eriksson, Mikael
Lambrechts, Dieter
Weltens, Caroline
Leunen, Karin
van Ongeval, Chantal
Nordestgaard, Børge G
Nielsen, Sune F
Flyger, Henrik
Rudolph, Anja
Seibold, Petra
Flesch-Janys, Dieter
Blomqvist, Carl
Aittomäki, Kristiina
Fagerholm, Rainer
Muranen, Taru A
Olsen, Janet E
Hallberg, Emily
Vachon, Celine
Knight, Julia A
Glendon, Gord
Mulligan, Anna Marie
Broeks, Annegien
Cornelissen, Sten
Haiman, Christopher A
Henderson, Brian E
Schumacher, Frederick
Le Marchand, Loic
Hopper, John L
Tsimiklis, Helen
Apicella, Carmel
Southey, Melissa C
Cross, Simon S
Reed, Malcolm WR
Giles, Graham G
Milne, Roger L
McLean, Catriona
Winqvist, Robert
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Hooning, Maartje J
Hollestelle, Antoinette
Martens, John WM
van den Ouweland, Ans MW
Marme, Federick
Schneeweiss, Andreas
Yang, Rongxi
Burwinkel, Barbara
Figueroa, Jonine
Chanock, Stephen J
Lissowska, Jolanta
Sawyer, Elinor J
Tomlinson, Ian
Kerin, Michael J
Miller, Nicola
Brenner, Hermann
Butterbach, Katja
Holleczek, Bernd
Kataja, Vesa
Kosma, Veli-Matti
Hartikainen, Jaana M
Li, Jingmei
Brand, Judith S
Humphreys, Keith
Devilee, Peter
Tollenaar, Robert AEM
Seynaeve, Caroline
Radice, Paolo
Peterlongo, Paolo
Manoukian, Siranoush
Ficarazzi, Filomena
Beckmann, Matthias W
Hein, Alexander
Ekici, Arif B
Balleine, Rosemary
Phillips, Kelly-Anne
Benitez, Javier
Zamora, M Pilar
Perez, Jose Ignacio Arias
Menéndez, Primitiva
Jakubowska, Anna
Lubinski, Jan
Gronwald, Jacek
Durda, Katarzyna
Hamann, Ute
Kabisch, Maria
Ulmer, Hans Ulrich
Rüdiger, Thomas
Margolin, Sara
Kristensen, Vessela
Nord, Siljie
Evans, D Gareth
Abraham, Jean
Earl, Helena
Poole, Christopher J
Hiller, Louise
Dunn, Janet A
Bowden, Sarah
Yang, Rose
Campa, Daniele
Diver, W Ryan
Gapstur, Susan M
Gaudet, Mia M
Hankinson, Susan
Hoover, Robert N
Hüsing, Anika
Kaaks, Rudolf
Machiela, Mitchell J
Willett, Walter
Barrdahl, Myrto
Canzian, Federico
Chin, Suet-Feung
Caldas, Carlos
Hunter, David J
Lindstrom, Sara
Garcia-Closas, Montserrat
Couch, Fergus J
Chenevix-Trench, Georgia
Mannermaa, Arto
Andrulis, Irene L
Hall, Per
Chang-Claude, Jenny
Easton, Douglas F
Bojesen, Stig E
Cox, Angela
Fasching, Peter A
Pharoah, Paul DP
Schmidt, Marjanka K
author_sort Pirie, Ailith
collection PubMed
description INTRODUCTION: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. METHODS: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value <0.05 were included. Single nucleotide polymorphisms that had been previously reported as nominally associated with at least one survival outcome were evaluated in the pooled analysis of over 37,000 breast cancer cases for association with breast cancer-specific survival. Previous associations were evaluated using a one-sided test based on the reported direction of effect. RESULTS: Fifty-six variants from 45 previous publications were evaluated in the meta-analysis. Fifty-four of these were evaluated in the full set of 37,954 breast cancer cases with 2,900 events and the two additional variants were evaluated in a reduced sample size of 30,000 samples in order to ensure independence from the previously published studies. Five variants reached nominal significance (P <0.05) in the pooled GWAS data compared to 2.8 expected under the null hypothesis. Seven additional variants were associated (P <0.05) with ER-positive disease. CONCLUSIONS: Although no variants reached genome-wide significance (P <5 x 10(−8)), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13058-015-0570-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-44847082015-06-30 Common germline polymorphisms associated with breast cancer-specific survival Pirie, Ailith Guo, Qi Kraft, Peter Canisius, Sander Eccles, Diana M Rahman, Nazneen Nevanlinna, Heli Chen, Constance Khan, Sofia Tyrer, Jonathan Bolla, Manjeet K Wang, Qin Dennis, Joe Michailidou, Kyriaki Lush, Michael Dunning, Alison M Shah, Mitul Czene, Kamila Darabi, Hatef Eriksson, Mikael Lambrechts, Dieter Weltens, Caroline Leunen, Karin van Ongeval, Chantal Nordestgaard, Børge G Nielsen, Sune F Flyger, Henrik Rudolph, Anja Seibold, Petra Flesch-Janys, Dieter Blomqvist, Carl Aittomäki, Kristiina Fagerholm, Rainer Muranen, Taru A Olsen, Janet E Hallberg, Emily Vachon, Celine Knight, Julia A Glendon, Gord Mulligan, Anna Marie Broeks, Annegien Cornelissen, Sten Haiman, Christopher A Henderson, Brian E Schumacher, Frederick Le Marchand, Loic Hopper, John L Tsimiklis, Helen Apicella, Carmel Southey, Melissa C Cross, Simon S Reed, Malcolm WR Giles, Graham G Milne, Roger L McLean, Catriona Winqvist, Robert Pylkäs, Katri Jukkola-Vuorinen, Arja Grip, Mervi Hooning, Maartje J Hollestelle, Antoinette Martens, John WM van den Ouweland, Ans MW Marme, Federick Schneeweiss, Andreas Yang, Rongxi Burwinkel, Barbara Figueroa, Jonine Chanock, Stephen J Lissowska, Jolanta Sawyer, Elinor J Tomlinson, Ian Kerin, Michael J Miller, Nicola Brenner, Hermann Butterbach, Katja Holleczek, Bernd Kataja, Vesa Kosma, Veli-Matti Hartikainen, Jaana M Li, Jingmei Brand, Judith S Humphreys, Keith Devilee, Peter Tollenaar, Robert AEM Seynaeve, Caroline Radice, Paolo Peterlongo, Paolo Manoukian, Siranoush Ficarazzi, Filomena Beckmann, Matthias W Hein, Alexander Ekici, Arif B Balleine, Rosemary Phillips, Kelly-Anne Benitez, Javier Zamora, M Pilar Perez, Jose Ignacio Arias Menéndez, Primitiva Jakubowska, Anna Lubinski, Jan Gronwald, Jacek Durda, Katarzyna Hamann, Ute Kabisch, Maria Ulmer, Hans Ulrich Rüdiger, Thomas Margolin, Sara Kristensen, Vessela Nord, Siljie Evans, D Gareth Abraham, Jean Earl, Helena Poole, Christopher J Hiller, Louise Dunn, Janet A Bowden, Sarah Yang, Rose Campa, Daniele Diver, W Ryan Gapstur, Susan M Gaudet, Mia M Hankinson, Susan Hoover, Robert N Hüsing, Anika Kaaks, Rudolf Machiela, Mitchell J Willett, Walter Barrdahl, Myrto Canzian, Federico Chin, Suet-Feung Caldas, Carlos Hunter, David J Lindstrom, Sara Garcia-Closas, Montserrat Couch, Fergus J Chenevix-Trench, Georgia Mannermaa, Arto Andrulis, Irene L Hall, Per Chang-Claude, Jenny Easton, Douglas F Bojesen, Stig E Cox, Angela Fasching, Peter A Pharoah, Paul DP Schmidt, Marjanka K Breast Cancer Res Research Article INTRODUCTION: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. METHODS: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value <0.05 were included. Single nucleotide polymorphisms that had been previously reported as nominally associated with at least one survival outcome were evaluated in the pooled analysis of over 37,000 breast cancer cases for association with breast cancer-specific survival. Previous associations were evaluated using a one-sided test based on the reported direction of effect. RESULTS: Fifty-six variants from 45 previous publications were evaluated in the meta-analysis. Fifty-four of these were evaluated in the full set of 37,954 breast cancer cases with 2,900 events and the two additional variants were evaluated in a reduced sample size of 30,000 samples in order to ensure independence from the previously published studies. Five variants reached nominal significance (P <0.05) in the pooled GWAS data compared to 2.8 expected under the null hypothesis. Seven additional variants were associated (P <0.05) with ER-positive disease. CONCLUSIONS: Although no variants reached genome-wide significance (P <5 x 10(−8)), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13058-015-0570-7) contains supplementary material, which is available to authorized users. BioMed Central 2015-04-22 2015 /pmc/articles/PMC4484708/ /pubmed/25897948 http://dx.doi.org/10.1186/s13058-015-0570-7 Text en © Pirie et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Pirie, Ailith
Guo, Qi
Kraft, Peter
Canisius, Sander
Eccles, Diana M
Rahman, Nazneen
Nevanlinna, Heli
Chen, Constance
Khan, Sofia
Tyrer, Jonathan
Bolla, Manjeet K
Wang, Qin
Dennis, Joe
Michailidou, Kyriaki
Lush, Michael
Dunning, Alison M
Shah, Mitul
Czene, Kamila
Darabi, Hatef
Eriksson, Mikael
Lambrechts, Dieter
Weltens, Caroline
Leunen, Karin
van Ongeval, Chantal
Nordestgaard, Børge G
Nielsen, Sune F
Flyger, Henrik
Rudolph, Anja
Seibold, Petra
Flesch-Janys, Dieter
Blomqvist, Carl
Aittomäki, Kristiina
Fagerholm, Rainer
Muranen, Taru A
Olsen, Janet E
Hallberg, Emily
Vachon, Celine
Knight, Julia A
Glendon, Gord
Mulligan, Anna Marie
Broeks, Annegien
Cornelissen, Sten
Haiman, Christopher A
Henderson, Brian E
Schumacher, Frederick
Le Marchand, Loic
Hopper, John L
Tsimiklis, Helen
Apicella, Carmel
Southey, Melissa C
Cross, Simon S
Reed, Malcolm WR
Giles, Graham G
Milne, Roger L
McLean, Catriona
Winqvist, Robert
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Hooning, Maartje J
Hollestelle, Antoinette
Martens, John WM
van den Ouweland, Ans MW
Marme, Federick
Schneeweiss, Andreas
Yang, Rongxi
Burwinkel, Barbara
Figueroa, Jonine
Chanock, Stephen J
Lissowska, Jolanta
Sawyer, Elinor J
Tomlinson, Ian
Kerin, Michael J
Miller, Nicola
Brenner, Hermann
Butterbach, Katja
Holleczek, Bernd
Kataja, Vesa
Kosma, Veli-Matti
Hartikainen, Jaana M
Li, Jingmei
Brand, Judith S
Humphreys, Keith
Devilee, Peter
Tollenaar, Robert AEM
Seynaeve, Caroline
Radice, Paolo
Peterlongo, Paolo
Manoukian, Siranoush
Ficarazzi, Filomena
Beckmann, Matthias W
Hein, Alexander
Ekici, Arif B
Balleine, Rosemary
Phillips, Kelly-Anne
Benitez, Javier
Zamora, M Pilar
Perez, Jose Ignacio Arias
Menéndez, Primitiva
Jakubowska, Anna
Lubinski, Jan
Gronwald, Jacek
Durda, Katarzyna
Hamann, Ute
Kabisch, Maria
Ulmer, Hans Ulrich
Rüdiger, Thomas
Margolin, Sara
Kristensen, Vessela
Nord, Siljie
Evans, D Gareth
Abraham, Jean
Earl, Helena
Poole, Christopher J
Hiller, Louise
Dunn, Janet A
Bowden, Sarah
Yang, Rose
Campa, Daniele
Diver, W Ryan
Gapstur, Susan M
Gaudet, Mia M
Hankinson, Susan
Hoover, Robert N
Hüsing, Anika
Kaaks, Rudolf
Machiela, Mitchell J
Willett, Walter
Barrdahl, Myrto
Canzian, Federico
Chin, Suet-Feung
Caldas, Carlos
Hunter, David J
Lindstrom, Sara
Garcia-Closas, Montserrat
Couch, Fergus J
Chenevix-Trench, Georgia
Mannermaa, Arto
Andrulis, Irene L
Hall, Per
Chang-Claude, Jenny
Easton, Douglas F
Bojesen, Stig E
Cox, Angela
Fasching, Peter A
Pharoah, Paul DP
Schmidt, Marjanka K
Common germline polymorphisms associated with breast cancer-specific survival
title Common germline polymorphisms associated with breast cancer-specific survival
title_full Common germline polymorphisms associated with breast cancer-specific survival
title_fullStr Common germline polymorphisms associated with breast cancer-specific survival
title_full_unstemmed Common germline polymorphisms associated with breast cancer-specific survival
title_short Common germline polymorphisms associated with breast cancer-specific survival
title_sort common germline polymorphisms associated with breast cancer-specific survival
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484708/
https://www.ncbi.nlm.nih.gov/pubmed/25897948
http://dx.doi.org/10.1186/s13058-015-0570-7
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AT pylkaskatri commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT jukkolavuorinenarja commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT gripmervi commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT hooningmaartjej commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT hollestelleantoinette commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT martensjohnwm commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT vandenouwelandansmw commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT marmefederick commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT schneeweissandreas commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT yangrongxi commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT burwinkelbarbara commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT figueroajonine commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT chanockstephenj commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT lissowskajolanta commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT sawyerelinorj commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT tomlinsonian commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT kerinmichaelj commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT millernicola commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT brennerhermann commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT butterbachkatja commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT holleczekbernd commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT katajavesa commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT kosmavelimatti commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT hartikainenjaanam commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT lijingmei commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT brandjudiths commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT humphreyskeith commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT devileepeter commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT tollenaarrobertaem commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT seynaevecaroline commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT radicepaolo commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT peterlongopaolo commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT manoukiansiranoush commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT ficarazzifilomena commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT beckmannmatthiasw commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT heinalexander commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT ekiciarifb commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT balleinerosemary commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT phillipskellyanne commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT benitezjavier commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT zamorampilar commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT perezjoseignacioarias commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT menendezprimitiva commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT jakubowskaanna commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT lubinskijan commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT gronwaldjacek commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT durdakatarzyna commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT hamannute commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT kabischmaria commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT ulmerhansulrich commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT rudigerthomas commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT margolinsara commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT kristensenvessela commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT nordsiljie commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT evansdgareth commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT abrahamjean commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT earlhelena commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT poolechristopherj commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT hillerlouise commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT dunnjaneta commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT bowdensarah commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT yangrose commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT campadaniele commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT diverwryan commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT gapstursusanm commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT gaudetmiam commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT hankinsonsusan commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT hooverrobertn commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT husinganika commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT kaaksrudolf commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT machielamitchellj commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT willettwalter commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT barrdahlmyrto commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT canzianfederico commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT chinsuetfeung commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT caldascarlos commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT hunterdavidj commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT lindstromsara commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT garciaclosasmontserrat commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT couchfergusj commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT chenevixtrenchgeorgia commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT mannermaaarto commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT andrulisirenel commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT hallper commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT changclaudejenny commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT eastondouglasf commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT bojesenstige commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT coxangela commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT faschingpetera commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT pharoahpauldp commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival
AT schmidtmarjankak commongermlinepolymorphismsassociatedwithbreastcancerspecificsurvival