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Kidney Transplantation in the Diabetic Patient
Diabetes mellitus is one of the most important causes of chronic kidney disease (CKD). In patients with advanced diabetic kidney disease, kidney transplantation (KT) with or without a pancreas transplant is the treatment of choice. We aimed to review current data regarding kidney and pancreas transp...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484999/ https://www.ncbi.nlm.nih.gov/pubmed/26239558 http://dx.doi.org/10.3390/jcm4061269 |
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author | Pérez-Sáez, María José Pascual, Julio |
author_facet | Pérez-Sáez, María José Pascual, Julio |
author_sort | Pérez-Sáez, María José |
collection | PubMed |
description | Diabetes mellitus is one of the most important causes of chronic kidney disease (CKD). In patients with advanced diabetic kidney disease, kidney transplantation (KT) with or without a pancreas transplant is the treatment of choice. We aimed to review current data regarding kidney and pancreas transplant options in patients with both type 1 and 2 diabetes and the outcomes of different treatment modalities. In general, pancreas transplantation is associated with long-term survival advantages despite an increased short-term morbidity and mortality risk. This applies to simultaneous pancreas kidney transplantation or pancreas after KT compared to KT alone (either living donor or deceased). Other factors as living donor availability, comorbidities, and expected waiting time have to be considered whens electing one transplant modality, rather than a clear benefit in survival of one strategy vs. others. In selected type 2 diabetic patients, data support cautious utilization of simultaneous pancreas kidney transplantation when a living kidney donor is not an option. Pancreas and kidney transplantation seems to be the treatment of choice for most type 1 diabetic and selected type 2 diabetic patients. |
format | Online Article Text |
id | pubmed-4484999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44849992015-07-28 Kidney Transplantation in the Diabetic Patient Pérez-Sáez, María José Pascual, Julio J Clin Med Review Diabetes mellitus is one of the most important causes of chronic kidney disease (CKD). In patients with advanced diabetic kidney disease, kidney transplantation (KT) with or without a pancreas transplant is the treatment of choice. We aimed to review current data regarding kidney and pancreas transplant options in patients with both type 1 and 2 diabetes and the outcomes of different treatment modalities. In general, pancreas transplantation is associated with long-term survival advantages despite an increased short-term morbidity and mortality risk. This applies to simultaneous pancreas kidney transplantation or pancreas after KT compared to KT alone (either living donor or deceased). Other factors as living donor availability, comorbidities, and expected waiting time have to be considered whens electing one transplant modality, rather than a clear benefit in survival of one strategy vs. others. In selected type 2 diabetic patients, data support cautious utilization of simultaneous pancreas kidney transplantation when a living kidney donor is not an option. Pancreas and kidney transplantation seems to be the treatment of choice for most type 1 diabetic and selected type 2 diabetic patients. MDPI 2015-06-09 /pmc/articles/PMC4484999/ /pubmed/26239558 http://dx.doi.org/10.3390/jcm4061269 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pérez-Sáez, María José Pascual, Julio Kidney Transplantation in the Diabetic Patient |
title | Kidney Transplantation in the Diabetic Patient |
title_full | Kidney Transplantation in the Diabetic Patient |
title_fullStr | Kidney Transplantation in the Diabetic Patient |
title_full_unstemmed | Kidney Transplantation in the Diabetic Patient |
title_short | Kidney Transplantation in the Diabetic Patient |
title_sort | kidney transplantation in the diabetic patient |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484999/ https://www.ncbi.nlm.nih.gov/pubmed/26239558 http://dx.doi.org/10.3390/jcm4061269 |
work_keys_str_mv | AT perezsaezmariajose kidneytransplantationinthediabeticpatient AT pascualjulio kidneytransplantationinthediabeticpatient |