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Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis

Matrix metalloproteinase-3 (MMP3) plays a key role in tissue degradation in periodontitis. The relationship between the MMP3 -1171 5A/6A polymorphism (rs35068180) and periodontitis has been widely studied. However, existing studies have yielded contradictory results. We therefore conducted a meta-an...

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Autores principales: Ding, Cheng, Chen, Xing, Zhang, Peng-tao, Huang, Jin-ping, Xu, Yan, Chen, Ning, Zhong, Liang-jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485030/
https://www.ncbi.nlm.nih.gov/pubmed/26123623
http://dx.doi.org/10.1038/srep11667
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author Ding, Cheng
Chen, Xing
Zhang, Peng-tao
Huang, Jin-ping
Xu, Yan
Chen, Ning
Zhong, Liang-jun
author_facet Ding, Cheng
Chen, Xing
Zhang, Peng-tao
Huang, Jin-ping
Xu, Yan
Chen, Ning
Zhong, Liang-jun
author_sort Ding, Cheng
collection PubMed
description Matrix metalloproteinase-3 (MMP3) plays a key role in tissue degradation in periodontitis. The relationship between the MMP3 -1171 5A/6A polymorphism (rs35068180) and periodontitis has been widely studied. However, existing studies have yielded contradictory results. We therefore conducted a meta-analysis to comprehensively investigate these inconclusive findings. Several electronic databases were searched for eligible articles. Seven case-control studies from 6 articles were searched without any language restrictions. Pooled estimates indicated that MMP3 -1171 5A/6A polymorphism is associated with a decreased risk of periodontitis (allelic genetic model: OR = 0.70, 95% CI: 0.62–0.80, P(heterogeneity) = 0.315; heterozygous model: OR = 0.50, 95% CI: 0.39–0.65, P(heterogeneity) = 0.221; homozygous model: OR = 0.42, 95% CI: 0.25–0.69, P(heterogeneity) = 0.265; dominant model: OR = 0.49, 95% CI: 0.38–0.62, P(heterogeneity) = 0.238, respectively). Similar results were also found in chronic periodontitis (CP), Asian, Asian&CP, and non-smokers subgroups. Moreover, MMP3 rs35068180 polymorphism might be associated with a lower risk of aggressive periodontitis (AgP) in Asians (allelic genetic model: OR = 0.66, 95% CI: 0.48–0.91, P(heterogeneity) = 0.945), and CP in Caucasians and Brazilians. In conclusion, this meta-analysis demonstrates that MMP3 -1171 5A/6A polymorphism may be associated with decreased risk of both CP and AgP in Asians. Large independent studies to replicate these results are necessary to validate these associations in other populations.
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spelling pubmed-44850302015-07-08 Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis Ding, Cheng Chen, Xing Zhang, Peng-tao Huang, Jin-ping Xu, Yan Chen, Ning Zhong, Liang-jun Sci Rep Article Matrix metalloproteinase-3 (MMP3) plays a key role in tissue degradation in periodontitis. The relationship between the MMP3 -1171 5A/6A polymorphism (rs35068180) and periodontitis has been widely studied. However, existing studies have yielded contradictory results. We therefore conducted a meta-analysis to comprehensively investigate these inconclusive findings. Several electronic databases were searched for eligible articles. Seven case-control studies from 6 articles were searched without any language restrictions. Pooled estimates indicated that MMP3 -1171 5A/6A polymorphism is associated with a decreased risk of periodontitis (allelic genetic model: OR = 0.70, 95% CI: 0.62–0.80, P(heterogeneity) = 0.315; heterozygous model: OR = 0.50, 95% CI: 0.39–0.65, P(heterogeneity) = 0.221; homozygous model: OR = 0.42, 95% CI: 0.25–0.69, P(heterogeneity) = 0.265; dominant model: OR = 0.49, 95% CI: 0.38–0.62, P(heterogeneity) = 0.238, respectively). Similar results were also found in chronic periodontitis (CP), Asian, Asian&CP, and non-smokers subgroups. Moreover, MMP3 rs35068180 polymorphism might be associated with a lower risk of aggressive periodontitis (AgP) in Asians (allelic genetic model: OR = 0.66, 95% CI: 0.48–0.91, P(heterogeneity) = 0.945), and CP in Caucasians and Brazilians. In conclusion, this meta-analysis demonstrates that MMP3 -1171 5A/6A polymorphism may be associated with decreased risk of both CP and AgP in Asians. Large independent studies to replicate these results are necessary to validate these associations in other populations. Nature Publishing Group 2015-06-30 /pmc/articles/PMC4485030/ /pubmed/26123623 http://dx.doi.org/10.1038/srep11667 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Ding, Cheng
Chen, Xing
Zhang, Peng-tao
Huang, Jin-ping
Xu, Yan
Chen, Ning
Zhong, Liang-jun
Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis
title Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis
title_full Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis
title_fullStr Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis
title_full_unstemmed Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis
title_short Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis
title_sort matrix metalloproteinase-3 -1171 5a/6a polymorphism (rs35068180) is associated with risk of periodontitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485030/
https://www.ncbi.nlm.nih.gov/pubmed/26123623
http://dx.doi.org/10.1038/srep11667
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