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The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila

Coordinating metabolism and feeding is important to avoid obesity and metabolic diseases, yet the underlying mechanisms, balancing nutrient intake and metabolic expenditure, are poorly understood. Several mechanisms controlling these processes are conserved in Drosophila, where homeostasis and energ...

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Autores principales: Hentze, Julie L., Carlsson, Mikael A., Kondo, Shu, Nässel, Dick R., Rewitz, Kim F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485031/
https://www.ncbi.nlm.nih.gov/pubmed/26123697
http://dx.doi.org/10.1038/srep11680
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author Hentze, Julie L.
Carlsson, Mikael A.
Kondo, Shu
Nässel, Dick R.
Rewitz, Kim F.
author_facet Hentze, Julie L.
Carlsson, Mikael A.
Kondo, Shu
Nässel, Dick R.
Rewitz, Kim F.
author_sort Hentze, Julie L.
collection PubMed
description Coordinating metabolism and feeding is important to avoid obesity and metabolic diseases, yet the underlying mechanisms, balancing nutrient intake and metabolic expenditure, are poorly understood. Several mechanisms controlling these processes are conserved in Drosophila, where homeostasis and energy mobilization are regulated by the glucagon-related adipokinetic hormone (AKH) and the Drosophila insulin-like peptides (DILPs). Here, we provide evidence that the Drosophila neuropeptide Allatostatin A (AstA) regulates AKH and DILP signaling. The AstA receptor gene, Dar-2, is expressed in both the insulin and AKH producing cells. Silencing of Dar-2 in these cells results in changes in gene expression and physiology associated with reduced DILP and AKH signaling and animals lacking AstA accumulate high lipid levels. This suggests that AstA is regulating the balance between DILP and AKH, believed to be important for the maintenance of nutrient homeostasis in response to changing ratios of dietary sugar and protein. Furthermore, AstA and Dar-2 are regulated differentially by dietary carbohydrates and protein and AstA-neuronal activity modulates feeding choices between these types of nutrients. Our results suggest that AstA is involved in assigning value to these nutrients to coordinate metabolic and feeding decisions, responses that are important to balance food intake according to metabolic needs.
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spelling pubmed-44850312015-07-08 The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila Hentze, Julie L. Carlsson, Mikael A. Kondo, Shu Nässel, Dick R. Rewitz, Kim F. Sci Rep Article Coordinating metabolism and feeding is important to avoid obesity and metabolic diseases, yet the underlying mechanisms, balancing nutrient intake and metabolic expenditure, are poorly understood. Several mechanisms controlling these processes are conserved in Drosophila, where homeostasis and energy mobilization are regulated by the glucagon-related adipokinetic hormone (AKH) and the Drosophila insulin-like peptides (DILPs). Here, we provide evidence that the Drosophila neuropeptide Allatostatin A (AstA) regulates AKH and DILP signaling. The AstA receptor gene, Dar-2, is expressed in both the insulin and AKH producing cells. Silencing of Dar-2 in these cells results in changes in gene expression and physiology associated with reduced DILP and AKH signaling and animals lacking AstA accumulate high lipid levels. This suggests that AstA is regulating the balance between DILP and AKH, believed to be important for the maintenance of nutrient homeostasis in response to changing ratios of dietary sugar and protein. Furthermore, AstA and Dar-2 are regulated differentially by dietary carbohydrates and protein and AstA-neuronal activity modulates feeding choices between these types of nutrients. Our results suggest that AstA is involved in assigning value to these nutrients to coordinate metabolic and feeding decisions, responses that are important to balance food intake according to metabolic needs. Nature Publishing Group 2015-06-30 /pmc/articles/PMC4485031/ /pubmed/26123697 http://dx.doi.org/10.1038/srep11680 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Hentze, Julie L.
Carlsson, Mikael A.
Kondo, Shu
Nässel, Dick R.
Rewitz, Kim F.
The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila
title The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila
title_full The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila
title_fullStr The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila
title_full_unstemmed The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila
title_short The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila
title_sort neuropeptide allatostatin a regulates metabolism and feeding decisions in drosophila
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485031/
https://www.ncbi.nlm.nih.gov/pubmed/26123697
http://dx.doi.org/10.1038/srep11680
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