Whole genome amplification with SurePlex results in better copy number alteration detection using sequencing data compared to the MALBAC method

Current whole genome amplification (WGA) methods lead to amplification bias resulting in over- and under-represented regions in the genome. Nevertheless, certain WGA methods, such as SurePlex and subsequent arrayCGH analysis, make it possible to detect copy number alterations (CNAs) at a 10 Mb resol...

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Detalles Bibliográficos
Autores principales: Deleye, Lieselot, Coninck, Dieter De, Christodoulou, Christodoulos, Sante, Tom, Dheedene, Annelies, Heindryckx, Björn, Abbeel, Etienne Van den, Sutter, Petra De, Menten, Björn, Deforce, Dieter, Nieuwerburgh, Filip Van
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485032/
https://www.ncbi.nlm.nih.gov/pubmed/26122179
http://dx.doi.org/10.1038/srep11711

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