Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes

This study investigates therapeutic efficacy of photothermal therapy (PTT) in an orthotropic xenograft model of bone metastasis of breast cancer. The near-infrared (NIR) irradiation on Multi-Walled Carbon Nanotubes (MWNTs) resulted in a rapid heat generation which increased with the MWNTs concentrat...

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Autores principales: Lin, Zhen, Liu, Yi, Ma, Xueming, Hu, Shaoyu, Zhang, Jiawei, Wu, Qian, Ye, Wenbin, Zhu, Siyuan, Yang, Dehong, Qu, Dongbin, Jiang, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485034/
https://www.ncbi.nlm.nih.gov/pubmed/26122018
http://dx.doi.org/10.1038/srep11709
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author Lin, Zhen
Liu, Yi
Ma, Xueming
Hu, Shaoyu
Zhang, Jiawei
Wu, Qian
Ye, Wenbin
Zhu, Siyuan
Yang, Dehong
Qu, Dongbin
Jiang, Jianming
author_facet Lin, Zhen
Liu, Yi
Ma, Xueming
Hu, Shaoyu
Zhang, Jiawei
Wu, Qian
Ye, Wenbin
Zhu, Siyuan
Yang, Dehong
Qu, Dongbin
Jiang, Jianming
author_sort Lin, Zhen
collection PubMed
description This study investigates therapeutic efficacy of photothermal therapy (PTT) in an orthotropic xenograft model of bone metastasis of breast cancer. The near-infrared (NIR) irradiation on Multi-Walled Carbon Nanotubes (MWNTs) resulted in a rapid heat generation which increased with the MWNTs concentration up to 100 μg/ml. MWNTs alone exhibited no toxicity, but inclusion of MWNTs dramatically decreased cell viability when combined with laser irradiation. Thermographic observation revealed that treatment with 10 μg MWNTs followed by NIR laser irradiation resulted in a rapid increase in temperature up to 73.4±11.98 °C in an intraosseous model of bone metastasis of breast cancer. In addition, MWNTs plus NIR laser irradiation caused a remarkably greater suppression of tumor growth compared with treatment with either MWNTs injection or NIR irradiation alone, significantly reducing the amount of tumor-induced bone destruction. All these demonstrate the efficacy of PTT with MWNTs for bone metastasis of breast cancer.
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spelling pubmed-44850342015-07-08 Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes Lin, Zhen Liu, Yi Ma, Xueming Hu, Shaoyu Zhang, Jiawei Wu, Qian Ye, Wenbin Zhu, Siyuan Yang, Dehong Qu, Dongbin Jiang, Jianming Sci Rep Article This study investigates therapeutic efficacy of photothermal therapy (PTT) in an orthotropic xenograft model of bone metastasis of breast cancer. The near-infrared (NIR) irradiation on Multi-Walled Carbon Nanotubes (MWNTs) resulted in a rapid heat generation which increased with the MWNTs concentration up to 100 μg/ml. MWNTs alone exhibited no toxicity, but inclusion of MWNTs dramatically decreased cell viability when combined with laser irradiation. Thermographic observation revealed that treatment with 10 μg MWNTs followed by NIR laser irradiation resulted in a rapid increase in temperature up to 73.4±11.98 °C in an intraosseous model of bone metastasis of breast cancer. In addition, MWNTs plus NIR laser irradiation caused a remarkably greater suppression of tumor growth compared with treatment with either MWNTs injection or NIR irradiation alone, significantly reducing the amount of tumor-induced bone destruction. All these demonstrate the efficacy of PTT with MWNTs for bone metastasis of breast cancer. Nature Publishing Group 2015-06-30 /pmc/articles/PMC4485034/ /pubmed/26122018 http://dx.doi.org/10.1038/srep11709 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lin, Zhen
Liu, Yi
Ma, Xueming
Hu, Shaoyu
Zhang, Jiawei
Wu, Qian
Ye, Wenbin
Zhu, Siyuan
Yang, Dehong
Qu, Dongbin
Jiang, Jianming
Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes
title Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes
title_full Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes
title_fullStr Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes
title_full_unstemmed Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes
title_short Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes
title_sort photothermal ablation of bone metastasis of breast cancer using pegylated multi-walled carbon nanotubes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485034/
https://www.ncbi.nlm.nih.gov/pubmed/26122018
http://dx.doi.org/10.1038/srep11709
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