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Socioeconomic Status and Childhood Leukemia Incidence in Switzerland
Socioeconomic status (SES) discrepancies exist for child and adult cancer morbidity and are a major public health concern. In this Swiss population-based matched case–control study on the etiology of childhood leukemia, we selected the cases from the Swiss Childhood Cancer Registry diagnosed since 1...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485172/ https://www.ncbi.nlm.nih.gov/pubmed/26175964 http://dx.doi.org/10.3389/fonc.2015.00139 |
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author | Adam, Martin Kuehni, Claudia E. Spoerri, Adrian Schmidlin, Kurt Gumy-Pause, Fabienne Brazzola, Pierluigi Probst-Hensch, Nicole Zwahlen, Marcel |
author_facet | Adam, Martin Kuehni, Claudia E. Spoerri, Adrian Schmidlin, Kurt Gumy-Pause, Fabienne Brazzola, Pierluigi Probst-Hensch, Nicole Zwahlen, Marcel |
author_sort | Adam, Martin |
collection | PubMed |
description | Socioeconomic status (SES) discrepancies exist for child and adult cancer morbidity and are a major public health concern. In this Swiss population-based matched case–control study on the etiology of childhood leukemia, we selected the cases from the Swiss Childhood Cancer Registry diagnosed since 1991 and the controls randomly from census. We assigned eight controls per case from the 1990 and 2000 census and matched them by the year of birth and gender. SES information for both cases and controls was obtained from census records by probabilistic record linkage. We investigated the association of SES with childhood leukemia in Switzerland, and explored whether it varied with different definitions of socioeconomic status (parental education, living condition, area-based SES), time period, and age. In conditional logistic regression analyses of 565 leukemia cases and 4433 controls, we found no consistent evidence for an association between SES and childhood leukemia. The odds ratio comparing the highest with the lowest SES category ranged from 0.95 (95% CI: 0.71–1.26; P(trend) = 0.73) for paternal education to 1.37 (1.00–1.89; P(trend) = 0.064) for maternal education. No effect modification was found for time period and age at diagnosis. Based on this population-based study, which avoided participation and reporting bias, we assume the potential association of socioeconomic status and childhood leukemia if existing to be small. This study did not find evidence that socioeconomic status, of Switzerland or comparable countries, is a relevant risk factor or strong confounder in etiological investigations on childhood leukemia. |
format | Online Article Text |
id | pubmed-4485172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44851722015-07-14 Socioeconomic Status and Childhood Leukemia Incidence in Switzerland Adam, Martin Kuehni, Claudia E. Spoerri, Adrian Schmidlin, Kurt Gumy-Pause, Fabienne Brazzola, Pierluigi Probst-Hensch, Nicole Zwahlen, Marcel Front Oncol Oncology Socioeconomic status (SES) discrepancies exist for child and adult cancer morbidity and are a major public health concern. In this Swiss population-based matched case–control study on the etiology of childhood leukemia, we selected the cases from the Swiss Childhood Cancer Registry diagnosed since 1991 and the controls randomly from census. We assigned eight controls per case from the 1990 and 2000 census and matched them by the year of birth and gender. SES information for both cases and controls was obtained from census records by probabilistic record linkage. We investigated the association of SES with childhood leukemia in Switzerland, and explored whether it varied with different definitions of socioeconomic status (parental education, living condition, area-based SES), time period, and age. In conditional logistic regression analyses of 565 leukemia cases and 4433 controls, we found no consistent evidence for an association between SES and childhood leukemia. The odds ratio comparing the highest with the lowest SES category ranged from 0.95 (95% CI: 0.71–1.26; P(trend) = 0.73) for paternal education to 1.37 (1.00–1.89; P(trend) = 0.064) for maternal education. No effect modification was found for time period and age at diagnosis. Based on this population-based study, which avoided participation and reporting bias, we assume the potential association of socioeconomic status and childhood leukemia if existing to be small. This study did not find evidence that socioeconomic status, of Switzerland or comparable countries, is a relevant risk factor or strong confounder in etiological investigations on childhood leukemia. Frontiers Media S.A. 2015-06-30 /pmc/articles/PMC4485172/ /pubmed/26175964 http://dx.doi.org/10.3389/fonc.2015.00139 Text en Copyright © 2015 Adam, Kuehni, Spoerri, Schmidlin, Gumy-Pause, Brazzola, Probst-Hensch and Zwahlen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Adam, Martin Kuehni, Claudia E. Spoerri, Adrian Schmidlin, Kurt Gumy-Pause, Fabienne Brazzola, Pierluigi Probst-Hensch, Nicole Zwahlen, Marcel Socioeconomic Status and Childhood Leukemia Incidence in Switzerland |
title | Socioeconomic Status and Childhood Leukemia Incidence in Switzerland |
title_full | Socioeconomic Status and Childhood Leukemia Incidence in Switzerland |
title_fullStr | Socioeconomic Status and Childhood Leukemia Incidence in Switzerland |
title_full_unstemmed | Socioeconomic Status and Childhood Leukemia Incidence in Switzerland |
title_short | Socioeconomic Status and Childhood Leukemia Incidence in Switzerland |
title_sort | socioeconomic status and childhood leukemia incidence in switzerland |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485172/ https://www.ncbi.nlm.nih.gov/pubmed/26175964 http://dx.doi.org/10.3389/fonc.2015.00139 |
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