Cargando…

Effect of dentate gyrus disruption on remembering what happened where

Our previous studies using Bax knockout (Bax-KO) mice, in which newly generated granule cells continue to accumulate, disrupting neural circuitry specifically in the dentate gyrus (DG), suggest the involvement of the DG in binding the internally-generated spatial map with sensory information on exte...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Woon Ryoung, Lee, Jong Won, Sun, Woong, Lee, Sung-Hyun, Choi, June-Seek, Jung, Min Whan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485174/
https://www.ncbi.nlm.nih.gov/pubmed/26175676
http://dx.doi.org/10.3389/fnbeh.2015.00170
_version_ 1782378742930210816
author Kim, Woon Ryoung
Lee, Jong Won
Sun, Woong
Lee, Sung-Hyun
Choi, June-Seek
Jung, Min Whan
author_facet Kim, Woon Ryoung
Lee, Jong Won
Sun, Woong
Lee, Sung-Hyun
Choi, June-Seek
Jung, Min Whan
author_sort Kim, Woon Ryoung
collection PubMed
description Our previous studies using Bax knockout (Bax-KO) mice, in which newly generated granule cells continue to accumulate, disrupting neural circuitry specifically in the dentate gyrus (DG), suggest the involvement of the DG in binding the internally-generated spatial map with sensory information on external landmarks (spatial map-object association) in forming a distinct spatial context for each environment. In order to test whether the DG is also involved in binding the internal spatial map with sensory information on external events (spatial map-event association), we tested the behavior of Bax-KO mice in a delayed-non-match-to-place task. Performance of Bax-KO mice was indistinguishable from that of wild-type mice as long as there was no interruption during the delay period (tested up to 5 min), suggesting that on-line maintenance of working memory is intact in Bax-KO mice. However, Bax-KO mice showed profound performance deficits when they were removed from the maze during the delay period (interruption condition) with a sufficiently long (65 s) delay, suggesting that episodic memory was impaired in Bax-KO mice. Together with previous findings, these results suggest the role of the DG in binding spatial information derived from dead reckoning and nonspatial information, such as external objects and events, in the process of encoding episodic memory.
format Online
Article
Text
id pubmed-4485174
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-44851742015-07-14 Effect of dentate gyrus disruption on remembering what happened where Kim, Woon Ryoung Lee, Jong Won Sun, Woong Lee, Sung-Hyun Choi, June-Seek Jung, Min Whan Front Behav Neurosci Neuroscience Our previous studies using Bax knockout (Bax-KO) mice, in which newly generated granule cells continue to accumulate, disrupting neural circuitry specifically in the dentate gyrus (DG), suggest the involvement of the DG in binding the internally-generated spatial map with sensory information on external landmarks (spatial map-object association) in forming a distinct spatial context for each environment. In order to test whether the DG is also involved in binding the internal spatial map with sensory information on external events (spatial map-event association), we tested the behavior of Bax-KO mice in a delayed-non-match-to-place task. Performance of Bax-KO mice was indistinguishable from that of wild-type mice as long as there was no interruption during the delay period (tested up to 5 min), suggesting that on-line maintenance of working memory is intact in Bax-KO mice. However, Bax-KO mice showed profound performance deficits when they were removed from the maze during the delay period (interruption condition) with a sufficiently long (65 s) delay, suggesting that episodic memory was impaired in Bax-KO mice. Together with previous findings, these results suggest the role of the DG in binding spatial information derived from dead reckoning and nonspatial information, such as external objects and events, in the process of encoding episodic memory. Frontiers Media S.A. 2015-06-30 /pmc/articles/PMC4485174/ /pubmed/26175676 http://dx.doi.org/10.3389/fnbeh.2015.00170 Text en Copyright © 2015 Kim, Lee, Sun, Lee, Choi and Jung. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kim, Woon Ryoung
Lee, Jong Won
Sun, Woong
Lee, Sung-Hyun
Choi, June-Seek
Jung, Min Whan
Effect of dentate gyrus disruption on remembering what happened where
title Effect of dentate gyrus disruption on remembering what happened where
title_full Effect of dentate gyrus disruption on remembering what happened where
title_fullStr Effect of dentate gyrus disruption on remembering what happened where
title_full_unstemmed Effect of dentate gyrus disruption on remembering what happened where
title_short Effect of dentate gyrus disruption on remembering what happened where
title_sort effect of dentate gyrus disruption on remembering what happened where
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485174/
https://www.ncbi.nlm.nih.gov/pubmed/26175676
http://dx.doi.org/10.3389/fnbeh.2015.00170
work_keys_str_mv AT kimwoonryoung effectofdentategyrusdisruptiononrememberingwhathappenedwhere
AT leejongwon effectofdentategyrusdisruptiononrememberingwhathappenedwhere
AT sunwoong effectofdentategyrusdisruptiononrememberingwhathappenedwhere
AT leesunghyun effectofdentategyrusdisruptiononrememberingwhathappenedwhere
AT choijuneseek effectofdentategyrusdisruptiononrememberingwhathappenedwhere
AT jungminwhan effectofdentategyrusdisruptiononrememberingwhathappenedwhere