Cargando…
B Cells and Functional Antibody Responses to Combat Influenza
Vaccination against influenza is the most effective way to protect the population. Current vaccines provide protection by stimulating functional B- and T-cell responses; however, they are poorly immunogenic in particular segments of the population and need to be reformulated almost every year due to...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485180/ https://www.ncbi.nlm.nih.gov/pubmed/26175732 http://dx.doi.org/10.3389/fimmu.2015.00336 |
_version_ | 1782378744262950912 |
---|---|
author | Lofano, Giuseppe Kumar, Arun Finco, Oretta Del Giudice, Giuseppe Bertholet, Sylvie |
author_facet | Lofano, Giuseppe Kumar, Arun Finco, Oretta Del Giudice, Giuseppe Bertholet, Sylvie |
author_sort | Lofano, Giuseppe |
collection | PubMed |
description | Vaccination against influenza is the most effective way to protect the population. Current vaccines provide protection by stimulating functional B- and T-cell responses; however, they are poorly immunogenic in particular segments of the population and need to be reformulated almost every year due to the genetic instability of the virus. Next-generation influenza vaccines should be designed to induce cross-reactivity, confer protection against pandemic outbreaks, and promote long-lasting immune responses among individuals at higher risk of infection. Multiple strategies are being developed for the induction of broad functional humoral immunity, including the use of adjuvants, heterologous prime-boost strategies, and epitope-based antigen design. The basic approach is to mimic natural responses to influenza virus infection by promoting cross-reactive neutralizing antibodies that directly prevent the infection. This review provides an overview of the mechanisms underlying humoral responses to influenza vaccination or natural infection, and discusses promising strategies to control influenza virus. |
format | Online Article Text |
id | pubmed-4485180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44851802015-07-14 B Cells and Functional Antibody Responses to Combat Influenza Lofano, Giuseppe Kumar, Arun Finco, Oretta Del Giudice, Giuseppe Bertholet, Sylvie Front Immunol Immunology Vaccination against influenza is the most effective way to protect the population. Current vaccines provide protection by stimulating functional B- and T-cell responses; however, they are poorly immunogenic in particular segments of the population and need to be reformulated almost every year due to the genetic instability of the virus. Next-generation influenza vaccines should be designed to induce cross-reactivity, confer protection against pandemic outbreaks, and promote long-lasting immune responses among individuals at higher risk of infection. Multiple strategies are being developed for the induction of broad functional humoral immunity, including the use of adjuvants, heterologous prime-boost strategies, and epitope-based antigen design. The basic approach is to mimic natural responses to influenza virus infection by promoting cross-reactive neutralizing antibodies that directly prevent the infection. This review provides an overview of the mechanisms underlying humoral responses to influenza vaccination or natural infection, and discusses promising strategies to control influenza virus. Frontiers Media S.A. 2015-06-30 /pmc/articles/PMC4485180/ /pubmed/26175732 http://dx.doi.org/10.3389/fimmu.2015.00336 Text en Copyright © 2015 Lofano, Kumar, Finco, Del Giudice and Bertholet. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Lofano, Giuseppe Kumar, Arun Finco, Oretta Del Giudice, Giuseppe Bertholet, Sylvie B Cells and Functional Antibody Responses to Combat Influenza |
title | B Cells and Functional Antibody Responses to Combat Influenza |
title_full | B Cells and Functional Antibody Responses to Combat Influenza |
title_fullStr | B Cells and Functional Antibody Responses to Combat Influenza |
title_full_unstemmed | B Cells and Functional Antibody Responses to Combat Influenza |
title_short | B Cells and Functional Antibody Responses to Combat Influenza |
title_sort | b cells and functional antibody responses to combat influenza |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485180/ https://www.ncbi.nlm.nih.gov/pubmed/26175732 http://dx.doi.org/10.3389/fimmu.2015.00336 |
work_keys_str_mv | AT lofanogiuseppe bcellsandfunctionalantibodyresponsestocombatinfluenza AT kumararun bcellsandfunctionalantibodyresponsestocombatinfluenza AT fincooretta bcellsandfunctionalantibodyresponsestocombatinfluenza AT delgiudicegiuseppe bcellsandfunctionalantibodyresponsestocombatinfluenza AT bertholetsylvie bcellsandfunctionalantibodyresponsestocombatinfluenza |