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Role of Energy Metabolism in the Brown Fat Gene Program
In murine and human brown adipose tissue (BAT), mitochondria are powerful generators of heat that safely metabolize fat, a feature that has great promise in the fight against obesity and diabetes. Recent studies suggest that the actions of mitochondria extend beyond their conventional role as genera...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485181/ https://www.ncbi.nlm.nih.gov/pubmed/26175716 http://dx.doi.org/10.3389/fendo.2015.00104 |
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author | Nam, Minwoo Cooper, Marcus P. |
author_facet | Nam, Minwoo Cooper, Marcus P. |
author_sort | Nam, Minwoo |
collection | PubMed |
description | In murine and human brown adipose tissue (BAT), mitochondria are powerful generators of heat that safely metabolize fat, a feature that has great promise in the fight against obesity and diabetes. Recent studies suggest that the actions of mitochondria extend beyond their conventional role as generators of heat. There is mounting evidence that impaired mitochondrial respiratory capacity is accompanied by attenuated expression of Ucp1 and other BAT-selective genes, implying that mitochondria exert transcriptional control over the brown fat gene program. In this review, we discuss the current understanding of brown fat mitochondria, their potential role in transcriptional control of the brown fat gene program, and potential strategies to treat obesity in humans by leveraging thermogenesis in brown adipocytes. |
format | Online Article Text |
id | pubmed-4485181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44851812015-07-14 Role of Energy Metabolism in the Brown Fat Gene Program Nam, Minwoo Cooper, Marcus P. Front Endocrinol (Lausanne) Endocrinology In murine and human brown adipose tissue (BAT), mitochondria are powerful generators of heat that safely metabolize fat, a feature that has great promise in the fight against obesity and diabetes. Recent studies suggest that the actions of mitochondria extend beyond their conventional role as generators of heat. There is mounting evidence that impaired mitochondrial respiratory capacity is accompanied by attenuated expression of Ucp1 and other BAT-selective genes, implying that mitochondria exert transcriptional control over the brown fat gene program. In this review, we discuss the current understanding of brown fat mitochondria, their potential role in transcriptional control of the brown fat gene program, and potential strategies to treat obesity in humans by leveraging thermogenesis in brown adipocytes. Frontiers Media S.A. 2015-06-30 /pmc/articles/PMC4485181/ /pubmed/26175716 http://dx.doi.org/10.3389/fendo.2015.00104 Text en Copyright © 2015 Nam and Cooper. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Nam, Minwoo Cooper, Marcus P. Role of Energy Metabolism in the Brown Fat Gene Program |
title | Role of Energy Metabolism in the Brown Fat Gene Program |
title_full | Role of Energy Metabolism in the Brown Fat Gene Program |
title_fullStr | Role of Energy Metabolism in the Brown Fat Gene Program |
title_full_unstemmed | Role of Energy Metabolism in the Brown Fat Gene Program |
title_short | Role of Energy Metabolism in the Brown Fat Gene Program |
title_sort | role of energy metabolism in the brown fat gene program |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485181/ https://www.ncbi.nlm.nih.gov/pubmed/26175716 http://dx.doi.org/10.3389/fendo.2015.00104 |
work_keys_str_mv | AT namminwoo roleofenergymetabolisminthebrownfatgeneprogram AT coopermarcusp roleofenergymetabolisminthebrownfatgeneprogram |