Cargando…

Role of Energy Metabolism in the Brown Fat Gene Program

In murine and human brown adipose tissue (BAT), mitochondria are powerful generators of heat that safely metabolize fat, a feature that has great promise in the fight against obesity and diabetes. Recent studies suggest that the actions of mitochondria extend beyond their conventional role as genera...

Descripción completa

Detalles Bibliográficos
Autores principales: Nam, Minwoo, Cooper, Marcus P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485181/
https://www.ncbi.nlm.nih.gov/pubmed/26175716
http://dx.doi.org/10.3389/fendo.2015.00104
_version_ 1782378744486297600
author Nam, Minwoo
Cooper, Marcus P.
author_facet Nam, Minwoo
Cooper, Marcus P.
author_sort Nam, Minwoo
collection PubMed
description In murine and human brown adipose tissue (BAT), mitochondria are powerful generators of heat that safely metabolize fat, a feature that has great promise in the fight against obesity and diabetes. Recent studies suggest that the actions of mitochondria extend beyond their conventional role as generators of heat. There is mounting evidence that impaired mitochondrial respiratory capacity is accompanied by attenuated expression of Ucp1 and other BAT-selective genes, implying that mitochondria exert transcriptional control over the brown fat gene program. In this review, we discuss the current understanding of brown fat mitochondria, their potential role in transcriptional control of the brown fat gene program, and potential strategies to treat obesity in humans by leveraging thermogenesis in brown adipocytes.
format Online
Article
Text
id pubmed-4485181
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-44851812015-07-14 Role of Energy Metabolism in the Brown Fat Gene Program Nam, Minwoo Cooper, Marcus P. Front Endocrinol (Lausanne) Endocrinology In murine and human brown adipose tissue (BAT), mitochondria are powerful generators of heat that safely metabolize fat, a feature that has great promise in the fight against obesity and diabetes. Recent studies suggest that the actions of mitochondria extend beyond their conventional role as generators of heat. There is mounting evidence that impaired mitochondrial respiratory capacity is accompanied by attenuated expression of Ucp1 and other BAT-selective genes, implying that mitochondria exert transcriptional control over the brown fat gene program. In this review, we discuss the current understanding of brown fat mitochondria, their potential role in transcriptional control of the brown fat gene program, and potential strategies to treat obesity in humans by leveraging thermogenesis in brown adipocytes. Frontiers Media S.A. 2015-06-30 /pmc/articles/PMC4485181/ /pubmed/26175716 http://dx.doi.org/10.3389/fendo.2015.00104 Text en Copyright © 2015 Nam and Cooper. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Nam, Minwoo
Cooper, Marcus P.
Role of Energy Metabolism in the Brown Fat Gene Program
title Role of Energy Metabolism in the Brown Fat Gene Program
title_full Role of Energy Metabolism in the Brown Fat Gene Program
title_fullStr Role of Energy Metabolism in the Brown Fat Gene Program
title_full_unstemmed Role of Energy Metabolism in the Brown Fat Gene Program
title_short Role of Energy Metabolism in the Brown Fat Gene Program
title_sort role of energy metabolism in the brown fat gene program
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485181/
https://www.ncbi.nlm.nih.gov/pubmed/26175716
http://dx.doi.org/10.3389/fendo.2015.00104
work_keys_str_mv AT namminwoo roleofenergymetabolisminthebrownfatgeneprogram
AT coopermarcusp roleofenergymetabolisminthebrownfatgeneprogram