How Does Thymus Infection by Coxsackievirus Contribute to the Pathogenesis of Type 1 Diabetes?

Through synthesis and presentation of neuroendocrine self-antigens by major histocompatibility complex proteins, thymic epithelial cells (TECs) play a crucial role in programing central immune self-tolerance to neuroendocrine functions. Insulin-like growth factor-2 (IGF-2) is the dominant gene/polyp...

Descripción completa

Detalles Bibliográficos
Autores principales: Michaux, Hélène, Martens, Henri, Jaïdane, Hela, Halouani, Aymen, Hober, Didier, Geenen, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485212/
https://www.ncbi.nlm.nih.gov/pubmed/26175734
http://dx.doi.org/10.3389/fimmu.2015.00338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485212/
https://www.ncbi.nlm.nih.gov/pubmed/26175734
http://dx.doi.org/10.3389/fimmu.2015.00338

Ejemplares similares