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Validity of C-reactive protein (CRP) for diagnosis of neonatal sepsis

OBJECTIVE: To determine the validity of C-reactive protein levels for diagnosis of neonatal sepsis. METHODS: A cross sectional (Validation) study was conducted at Neonatology unit in KRL general hospital (emergency/OPD) of 7 months duration from February 2012 to August 2012. By using purposive sampl...

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Autores principales: Hisamuddin, Effat, Hisam, Aliya, Wahid, Sughra, Raza, Ghulam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485264/
https://www.ncbi.nlm.nih.gov/pubmed/26150837
http://dx.doi.org/10.12669/pjms.313.6668
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author Hisamuddin, Effat
Hisam, Aliya
Wahid, Sughra
Raza, Ghulam
author_facet Hisamuddin, Effat
Hisam, Aliya
Wahid, Sughra
Raza, Ghulam
author_sort Hisamuddin, Effat
collection PubMed
description OBJECTIVE: To determine the validity of C-reactive protein levels for diagnosis of neonatal sepsis. METHODS: A cross sectional (Validation) study was conducted at Neonatology unit in KRL general hospital (emergency/OPD) of 7 months duration from February 2012 to August 2012. By using purposive sampling technique, 147, sample size was calculated by using WHO sample size calculator taking sensitivity 75%, specificity 95%, expected prevalence 50%, desired precision 10% and confidence level 95%. RESULTS: Mean age of the neonates was 5.72 days + 3.86. Male patients were 81(55.1%) while 66(44.9%) were female. Neonatal sepsis was observed in 43(29.25%) and were confirmed through blood culture while 104(70.75%) were not confirmed on blood culture as neonatal sepsis. The sensitivity and specificity of CRP in diagnosis of acute neonatal sepsis was 76.92% and 53.49% respectively while it had a positive predictive value of 80% and negative predictive value of 48.94%. Over all the diagnostic accuracy of CRP in diagnosis of neonatal sepsis was 70.07%. CONCLUSION: CRP estimation does have a role in the diagnosis of neonatal sepsis but the test is not specific enough to be relied upon as the only indicator.
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spelling pubmed-44852642015-07-06 Validity of C-reactive protein (CRP) for diagnosis of neonatal sepsis Hisamuddin, Effat Hisam, Aliya Wahid, Sughra Raza, Ghulam Pak J Med Sci Original Article OBJECTIVE: To determine the validity of C-reactive protein levels for diagnosis of neonatal sepsis. METHODS: A cross sectional (Validation) study was conducted at Neonatology unit in KRL general hospital (emergency/OPD) of 7 months duration from February 2012 to August 2012. By using purposive sampling technique, 147, sample size was calculated by using WHO sample size calculator taking sensitivity 75%, specificity 95%, expected prevalence 50%, desired precision 10% and confidence level 95%. RESULTS: Mean age of the neonates was 5.72 days + 3.86. Male patients were 81(55.1%) while 66(44.9%) were female. Neonatal sepsis was observed in 43(29.25%) and were confirmed through blood culture while 104(70.75%) were not confirmed on blood culture as neonatal sepsis. The sensitivity and specificity of CRP in diagnosis of acute neonatal sepsis was 76.92% and 53.49% respectively while it had a positive predictive value of 80% and negative predictive value of 48.94%. Over all the diagnostic accuracy of CRP in diagnosis of neonatal sepsis was 70.07%. CONCLUSION: CRP estimation does have a role in the diagnosis of neonatal sepsis but the test is not specific enough to be relied upon as the only indicator. Professional Medical Publications 2015 /pmc/articles/PMC4485264/ /pubmed/26150837 http://dx.doi.org/10.12669/pjms.313.6668 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hisamuddin, Effat
Hisam, Aliya
Wahid, Sughra
Raza, Ghulam
Validity of C-reactive protein (CRP) for diagnosis of neonatal sepsis
title Validity of C-reactive protein (CRP) for diagnosis of neonatal sepsis
title_full Validity of C-reactive protein (CRP) for diagnosis of neonatal sepsis
title_fullStr Validity of C-reactive protein (CRP) for diagnosis of neonatal sepsis
title_full_unstemmed Validity of C-reactive protein (CRP) for diagnosis of neonatal sepsis
title_short Validity of C-reactive protein (CRP) for diagnosis of neonatal sepsis
title_sort validity of c-reactive protein (crp) for diagnosis of neonatal sepsis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485264/
https://www.ncbi.nlm.nih.gov/pubmed/26150837
http://dx.doi.org/10.12669/pjms.313.6668
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