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Low density lipoprotein cholesterol control status among Canadians at risk for cardiovascular disease: findings from the Canadian Primary Care Sentinel Surveillance Network Database

BACKGROUND: To determine the prevalence of uncontrolled LDL-C in patients with high cardiovascular disease (CVD) risks across Canada and to examine its related factors. METHODS: Non-pregnant adults >20 years-old, who had a lipid test completed between January 1, 2009 and December 31, 2011 and wer...

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Autores principales: Aref-Eshghi, Erfan, Leung, Jason, Godwin, Marshall, Duke, Pauline, Williamson, Tyler, Mahdavian, Masoud, Asghari, Shabnam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485341/
https://www.ncbi.nlm.nih.gov/pubmed/26104310
http://dx.doi.org/10.1186/s12944-015-0056-8
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author Aref-Eshghi, Erfan
Leung, Jason
Godwin, Marshall
Duke, Pauline
Williamson, Tyler
Mahdavian, Masoud
Asghari, Shabnam
author_facet Aref-Eshghi, Erfan
Leung, Jason
Godwin, Marshall
Duke, Pauline
Williamson, Tyler
Mahdavian, Masoud
Asghari, Shabnam
author_sort Aref-Eshghi, Erfan
collection PubMed
description BACKGROUND: To determine the prevalence of uncontrolled LDL-C in patients with high cardiovascular disease (CVD) risks across Canada and to examine its related factors. METHODS: Non-pregnant adults >20 years-old, who had a lipid test completed between January 1, 2009 and December 31, 2011 and were included in the Canadian Primary Care Surveillance Network (CPCSSN) database were studied. The Framingham-Risk-Score was calculated to determine the risk levels. A serum LDL-C level of >2.0 mmol/L was considered as being poorly controlled. Patients with a previous record of a cerebrovascular accident, peripheral artery disease, or an ischemic heart disease were regarded as those under secondary prevention. Logistic regression modeling was performed to examine the factors associated with the LDL-C control. RESULTS: A total of 6,405 high-risk patients were included in the study and, of this population, 68 % had a suboptimal LDL-C, which was significantly associated with the female gender (OR: 3.26; 95 % CI: 2.63–4.05, p < 0.0001) and no medication therapy (OR: 6.31, 95 % CI: 5.21–7.65, p < 0.0001). Those with comorbidities of diabetes, hypertension, obesity, and smokers had a better LDL-C control. Rural residents (OR: 0.64, 95 % CI: 0.52–0.78, p < 0.0001), and those under secondary prevention (OR: 0.42; 95 % CI: 0.35–0.51, p < 0.0001), were also more likely to have a better LDL-C control. CONCLUSION: A high proportion of high-cardiac risk patients in Canadian primary care settings have suboptimal LDL-C control. A lack of medication therapy appears to be the major contributing factor to this situation.
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spelling pubmed-44853412015-07-01 Low density lipoprotein cholesterol control status among Canadians at risk for cardiovascular disease: findings from the Canadian Primary Care Sentinel Surveillance Network Database Aref-Eshghi, Erfan Leung, Jason Godwin, Marshall Duke, Pauline Williamson, Tyler Mahdavian, Masoud Asghari, Shabnam Lipids Health Dis Research BACKGROUND: To determine the prevalence of uncontrolled LDL-C in patients with high cardiovascular disease (CVD) risks across Canada and to examine its related factors. METHODS: Non-pregnant adults >20 years-old, who had a lipid test completed between January 1, 2009 and December 31, 2011 and were included in the Canadian Primary Care Surveillance Network (CPCSSN) database were studied. The Framingham-Risk-Score was calculated to determine the risk levels. A serum LDL-C level of >2.0 mmol/L was considered as being poorly controlled. Patients with a previous record of a cerebrovascular accident, peripheral artery disease, or an ischemic heart disease were regarded as those under secondary prevention. Logistic regression modeling was performed to examine the factors associated with the LDL-C control. RESULTS: A total of 6,405 high-risk patients were included in the study and, of this population, 68 % had a suboptimal LDL-C, which was significantly associated with the female gender (OR: 3.26; 95 % CI: 2.63–4.05, p < 0.0001) and no medication therapy (OR: 6.31, 95 % CI: 5.21–7.65, p < 0.0001). Those with comorbidities of diabetes, hypertension, obesity, and smokers had a better LDL-C control. Rural residents (OR: 0.64, 95 % CI: 0.52–0.78, p < 0.0001), and those under secondary prevention (OR: 0.42; 95 % CI: 0.35–0.51, p < 0.0001), were also more likely to have a better LDL-C control. CONCLUSION: A high proportion of high-cardiac risk patients in Canadian primary care settings have suboptimal LDL-C control. A lack of medication therapy appears to be the major contributing factor to this situation. BioMed Central 2015-06-24 /pmc/articles/PMC4485341/ /pubmed/26104310 http://dx.doi.org/10.1186/s12944-015-0056-8 Text en © Aref-Eshghi et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Aref-Eshghi, Erfan
Leung, Jason
Godwin, Marshall
Duke, Pauline
Williamson, Tyler
Mahdavian, Masoud
Asghari, Shabnam
Low density lipoprotein cholesterol control status among Canadians at risk for cardiovascular disease: findings from the Canadian Primary Care Sentinel Surveillance Network Database
title Low density lipoprotein cholesterol control status among Canadians at risk for cardiovascular disease: findings from the Canadian Primary Care Sentinel Surveillance Network Database
title_full Low density lipoprotein cholesterol control status among Canadians at risk for cardiovascular disease: findings from the Canadian Primary Care Sentinel Surveillance Network Database
title_fullStr Low density lipoprotein cholesterol control status among Canadians at risk for cardiovascular disease: findings from the Canadian Primary Care Sentinel Surveillance Network Database
title_full_unstemmed Low density lipoprotein cholesterol control status among Canadians at risk for cardiovascular disease: findings from the Canadian Primary Care Sentinel Surveillance Network Database
title_short Low density lipoprotein cholesterol control status among Canadians at risk for cardiovascular disease: findings from the Canadian Primary Care Sentinel Surveillance Network Database
title_sort low density lipoprotein cholesterol control status among canadians at risk for cardiovascular disease: findings from the canadian primary care sentinel surveillance network database
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485341/
https://www.ncbi.nlm.nih.gov/pubmed/26104310
http://dx.doi.org/10.1186/s12944-015-0056-8
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