Pleiotropic Effects of Bitter Taste Receptors on [Ca(2+)](i) Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells

Asthma is characterized by airway inflammation and airflow obstruction from human airway smooth muscle (HASM) constriction due to increased local bronchoconstrictive substances. We have recently found bitter taste receptors (TAS2Rs) on HASM, which increase [Ca(2+)](i) and relax the muscle. We report...

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Detalles Bibliográficos
Autores principales: Camoretti-Mercado, Blanca, Pauer, Susan H., Yong, Hwan Mee, Smith, Dan’elle C., Deshpande, Deepak A., An, Steven S., Liggett, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485472/
https://www.ncbi.nlm.nih.gov/pubmed/26121686
http://dx.doi.org/10.1371/journal.pone.0131582

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