Cargando…

Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress

The aim of the study was to determine whether or not dexmedetomidine- (DEX-) based intravenous infusion in dental implantation can provide better sedation and postoperative analgesia via suppressing postoperative inflammation and oxidative stress. Sixty patients were randomly assigned to receive eit...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Sisi, Yang, Yang, Yu, Cong, Yao, Ying, Wu, Yujia, Qian, Lian, Cheung, Chi Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485522/
https://www.ncbi.nlm.nih.gov/pubmed/26171113
http://dx.doi.org/10.1155/2015/186736
_version_ 1782378792406220800
author Li, Sisi
Yang, Yang
Yu, Cong
Yao, Ying
Wu, Yujia
Qian, Lian
Cheung, Chi Wai
author_facet Li, Sisi
Yang, Yang
Yu, Cong
Yao, Ying
Wu, Yujia
Qian, Lian
Cheung, Chi Wai
author_sort Li, Sisi
collection PubMed
description The aim of the study was to determine whether or not dexmedetomidine- (DEX-) based intravenous infusion in dental implantation can provide better sedation and postoperative analgesia via suppressing postoperative inflammation and oxidative stress. Sixty patients were randomly assigned to receive either DEX (group D) or midazolam (group M). Recorded variables were vital sign (SBP/HR/RPP/SpO(2)/RR), visual analogue scale (VAS) pain scores, and observer's assessment of alertness/sedation scale (OAAS) scores. The plasma levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), antioxidant superoxide dismutase (SOD), and the lipid peroxidation product malondialdehyde (MDA) were detected at baseline and after 2, 4, and 24 h of drug administration. The VAS pain scores and OAAS scores were significantly lower for patients in group D compared to group M. The plasma levels of TNF-α, IL-6, and MDA were significantly lower in group D patients than those in group M at 2 h and 4 h. In group M, SOD levels decreased as compared to group D at 2 h and 4 h. The plasma levels of TNF-α, IL-6, and MDA were positively correlated with VAS pain scores while SOD negatively correlated with VAS pain scores. Therefore, DEX appears to provide better sedation during office-based artificial tooth implantation. DEX offers better postoperative analgesia via anti-inflammatory and antioxidation pathway.
format Online
Article
Text
id pubmed-4485522
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-44855222015-07-13 Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress Li, Sisi Yang, Yang Yu, Cong Yao, Ying Wu, Yujia Qian, Lian Cheung, Chi Wai Oxid Med Cell Longev Clinical Study The aim of the study was to determine whether or not dexmedetomidine- (DEX-) based intravenous infusion in dental implantation can provide better sedation and postoperative analgesia via suppressing postoperative inflammation and oxidative stress. Sixty patients were randomly assigned to receive either DEX (group D) or midazolam (group M). Recorded variables were vital sign (SBP/HR/RPP/SpO(2)/RR), visual analogue scale (VAS) pain scores, and observer's assessment of alertness/sedation scale (OAAS) scores. The plasma levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), antioxidant superoxide dismutase (SOD), and the lipid peroxidation product malondialdehyde (MDA) were detected at baseline and after 2, 4, and 24 h of drug administration. The VAS pain scores and OAAS scores were significantly lower for patients in group D compared to group M. The plasma levels of TNF-α, IL-6, and MDA were significantly lower in group D patients than those in group M at 2 h and 4 h. In group M, SOD levels decreased as compared to group D at 2 h and 4 h. The plasma levels of TNF-α, IL-6, and MDA were positively correlated with VAS pain scores while SOD negatively correlated with VAS pain scores. Therefore, DEX appears to provide better sedation during office-based artificial tooth implantation. DEX offers better postoperative analgesia via anti-inflammatory and antioxidation pathway. Hindawi Publishing Corporation 2015 2015-06-15 /pmc/articles/PMC4485522/ /pubmed/26171113 http://dx.doi.org/10.1155/2015/186736 Text en Copyright © 2015 Sisi Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Li, Sisi
Yang, Yang
Yu, Cong
Yao, Ying
Wu, Yujia
Qian, Lian
Cheung, Chi Wai
Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress
title Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress
title_full Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress
title_fullStr Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress
title_full_unstemmed Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress
title_short Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress
title_sort dexmedetomidine analgesia effects in patients undergoing dental implant surgery and its impact on postoperative inflammatory and oxidative stress
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485522/
https://www.ncbi.nlm.nih.gov/pubmed/26171113
http://dx.doi.org/10.1155/2015/186736
work_keys_str_mv AT lisisi dexmedetomidineanalgesiaeffectsinpatientsundergoingdentalimplantsurgeryanditsimpactonpostoperativeinflammatoryandoxidativestress
AT yangyang dexmedetomidineanalgesiaeffectsinpatientsundergoingdentalimplantsurgeryanditsimpactonpostoperativeinflammatoryandoxidativestress
AT yucong dexmedetomidineanalgesiaeffectsinpatientsundergoingdentalimplantsurgeryanditsimpactonpostoperativeinflammatoryandoxidativestress
AT yaoying dexmedetomidineanalgesiaeffectsinpatientsundergoingdentalimplantsurgeryanditsimpactonpostoperativeinflammatoryandoxidativestress
AT wuyujia dexmedetomidineanalgesiaeffectsinpatientsundergoingdentalimplantsurgeryanditsimpactonpostoperativeinflammatoryandoxidativestress
AT qianlian dexmedetomidineanalgesiaeffectsinpatientsundergoingdentalimplantsurgeryanditsimpactonpostoperativeinflammatoryandoxidativestress
AT cheungchiwai dexmedetomidineanalgesiaeffectsinpatientsundergoingdentalimplantsurgeryanditsimpactonpostoperativeinflammatoryandoxidativestress