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Quantitative MR Markers and Psychiatric Symptoms in a Patient with Fahr Disease
Patient: Female, 43 Final Diagnosis: Fahr disease Symptoms: Movement disorder • chorea and tremors • cognitive deficit • behavioral aggressiveness and restlessness • visual hallucination Medication: Haloperidolo • levomepromazine • sodium valproate Clinical Procedure: Neurology examination • neurops...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485651/ https://www.ncbi.nlm.nih.gov/pubmed/26094250 http://dx.doi.org/10.12659/AJCR.893163 |
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author | Buono, Viviana Lo Corallo, Francesco Costa, Antonio Bramanti, Placido Marino, Silvia |
author_facet | Buono, Viviana Lo Corallo, Francesco Costa, Antonio Bramanti, Placido Marino, Silvia |
author_sort | Buono, Viviana Lo |
collection | PubMed |
description | Patient: Female, 43 Final Diagnosis: Fahr disease Symptoms: Movement disorder • chorea and tremors • cognitive deficit • behavioral aggressiveness and restlessness • visual hallucination Medication: Haloperidolo • levomepromazine • sodium valproate Clinical Procedure: Neurology examination • neuropsychological examination • MRI Specialty: Neurology OBJECTIVE: Rare disease BACKGROUND: Fahr’s disease (FD), or primitive idiopathic calcification of the basal ganglia, is a rare neurodegenerative syndrome characterized by the presence of idiopathic bilateral and symmetrical cerebral calcifications. CASE REPORT: We describe the case of 43-year-old woman presenting with psychiatric symptoms, disorganized behavior, and migraine. Magnetic resonance imaging (MRI) examination showed basal ganglia calcifications. In addition, we analyzed the cortical brain volume and noted cortical atrophy. Extensive etiological clinico-biological assessment allowed us to exclude known causes of brain calcifications and to diagnose Fahr disease (FD). Neurological symptoms associated with psychiatric manifestations are not uncommon in FD. CONCLUSIONS: Purely psychiatric presentations are possible, as demonstrated by the present case, although there have been very few cases reported. To date, no studies related to the brain atrophy in FD have been reported. |
format | Online Article Text |
id | pubmed-4485651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44856512015-07-09 Quantitative MR Markers and Psychiatric Symptoms in a Patient with Fahr Disease Buono, Viviana Lo Corallo, Francesco Costa, Antonio Bramanti, Placido Marino, Silvia Am J Case Rep Articles Patient: Female, 43 Final Diagnosis: Fahr disease Symptoms: Movement disorder • chorea and tremors • cognitive deficit • behavioral aggressiveness and restlessness • visual hallucination Medication: Haloperidolo • levomepromazine • sodium valproate Clinical Procedure: Neurology examination • neuropsychological examination • MRI Specialty: Neurology OBJECTIVE: Rare disease BACKGROUND: Fahr’s disease (FD), or primitive idiopathic calcification of the basal ganglia, is a rare neurodegenerative syndrome characterized by the presence of idiopathic bilateral and symmetrical cerebral calcifications. CASE REPORT: We describe the case of 43-year-old woman presenting with psychiatric symptoms, disorganized behavior, and migraine. Magnetic resonance imaging (MRI) examination showed basal ganglia calcifications. In addition, we analyzed the cortical brain volume and noted cortical atrophy. Extensive etiological clinico-biological assessment allowed us to exclude known causes of brain calcifications and to diagnose Fahr disease (FD). Neurological symptoms associated with psychiatric manifestations are not uncommon in FD. CONCLUSIONS: Purely psychiatric presentations are possible, as demonstrated by the present case, although there have been very few cases reported. To date, no studies related to the brain atrophy in FD have been reported. International Scientific Literature, Inc. 2015-06-21 /pmc/articles/PMC4485651/ /pubmed/26094250 http://dx.doi.org/10.12659/AJCR.893163 Text en © Am J Case Rep, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Articles Buono, Viviana Lo Corallo, Francesco Costa, Antonio Bramanti, Placido Marino, Silvia Quantitative MR Markers and Psychiatric Symptoms in a Patient with Fahr Disease |
title | Quantitative MR Markers and Psychiatric Symptoms in a Patient with Fahr Disease |
title_full | Quantitative MR Markers and Psychiatric Symptoms in a Patient with Fahr Disease |
title_fullStr | Quantitative MR Markers and Psychiatric Symptoms in a Patient with Fahr Disease |
title_full_unstemmed | Quantitative MR Markers and Psychiatric Symptoms in a Patient with Fahr Disease |
title_short | Quantitative MR Markers and Psychiatric Symptoms in a Patient with Fahr Disease |
title_sort | quantitative mr markers and psychiatric symptoms in a patient with fahr disease |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485651/ https://www.ncbi.nlm.nih.gov/pubmed/26094250 http://dx.doi.org/10.12659/AJCR.893163 |
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