Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8(+) T-cell response and robust cellular and transcriptional immune activation at tumor site in a patient with ovarian cancer

Adenoviruses are excellent immunotherapeutic agents with a unique ability to prime and boost immune responses. Recombinant adenoviruses cause immunogenic cancer cell death and subsequent release of tumor antigens for antigen presenting cells, resulting in the priming of potent tumor-specific immunit...

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Detalles Bibliográficos
Autores principales: Vassilev, L, Ranki, T, Joensuu, T, Jäger, E, Karbach, J, Wahle, C, Partanen, K, Kairemo, K, Alanko, T, Turkki, R, Linder, N, Lundin, J, Ristimäki, A, Kankainen, M, Hemminki, A, Backman, C, Dienel, K, von Euler, M, Haavisto, E, Hakonen, T, Juhila, J, Jäderberg, M, Priha, P, Vuolanto, A, Pesonen, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485730/
https://www.ncbi.nlm.nih.gov/pubmed/26140248
http://dx.doi.org/10.1080/2162402X.2015.1017702

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