Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies

We have developed a highly versatile platform for the systematic retrieval of T-cell receptors (TCRs) from single-antigen-reactive T cells and for characterization of their function and specificity. This approach enables rapid extraction of multiple TCRs from repertoires in individuals and not only...

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Detalles Bibliográficos
Autores principales: Omokoko, Tana, Simon, Petra, Türeci, Özlem, Sahin, Ugur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485745/
https://www.ncbi.nlm.nih.gov/pubmed/26140230
http://dx.doi.org/10.1080/2162402X.2015.1005523
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author Omokoko, Tana
Simon, Petra
Türeci, Özlem
Sahin, Ugur
author_facet Omokoko, Tana
Simon, Petra
Türeci, Özlem
Sahin, Ugur
author_sort Omokoko, Tana
collection PubMed
description We have developed a highly versatile platform for the systematic retrieval of T-cell receptors (TCRs) from single-antigen-reactive T cells and for characterization of their function and specificity. This approach enables rapid extraction of multiple TCRs from repertoires in individuals and not only broadens the diversity of TCRs suitable for clinical use, but also sets the stage for actively personalized immunotherapeutic strategies.
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spelling pubmed-44857452016-02-03 Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies Omokoko, Tana Simon, Petra Türeci, Özlem Sahin, Ugur Oncoimmunology Author's View We have developed a highly versatile platform for the systematic retrieval of T-cell receptors (TCRs) from single-antigen-reactive T cells and for characterization of their function and specificity. This approach enables rapid extraction of multiple TCRs from repertoires in individuals and not only broadens the diversity of TCRs suitable for clinical use, but also sets the stage for actively personalized immunotherapeutic strategies. Taylor & Francis 2015-03-19 /pmc/articles/PMC4485745/ /pubmed/26140230 http://dx.doi.org/10.1080/2162402X.2015.1005523 Text en © 2015 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Omokoko, Tana
Simon, Petra
Türeci, Özlem
Sahin, Ugur
Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies
title Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies
title_full Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies
title_fullStr Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies
title_full_unstemmed Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies
title_short Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies
title_sort retrieval of functional tcrs from single antigen-specific t cells: toward individualized tcr-engineered therapies
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485745/
https://www.ncbi.nlm.nih.gov/pubmed/26140230
http://dx.doi.org/10.1080/2162402X.2015.1005523
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AT tureciozlem retrievaloffunctionaltcrsfromsingleantigenspecifictcellstowardindividualizedtcrengineeredtherapies
AT sahinugur retrievaloffunctionaltcrsfromsingleantigenspecifictcellstowardindividualizedtcrengineeredtherapies

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