Cargando…

Akt1 and -2 inhibition diminishes terminal differentiation and enhances central memory CD8(+) T-cell proliferation and survival

The CD8(+) T-cell response comprises terminally differentiated effector cells and antigen-experienced memory T cells. The latter encompass central (T(CM)) and effector (T(EM)) memory cells. T(CM) cells are superior in their protection against viral and bacterial challenges and mediation of antitumor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abu Eid, Rasha, Friedman, Kevin M, Mkrtichyan, Mikayel, Walens, Andrea, King, William, Janik, John, Khleif, Samir N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485779/ https://www.ncbi.nlm.nih.gov/pubmed/26155399 http://dx.doi.org/10.1080/2162402X.2015.1005448

Ejemplares similares

AKT inhibition mitigates terminal differentiation and preserves central memory phenotype of CD8 T cells
por: Abu Eid, Rasha, et al.
Publicado: (2014)

Functional redundancy of PI3K isoforms in conventional T cells provides a selective Treg-targeting strategy through inhibition of PI3K-delta isoform
por: Ahmad, Shamim, et al.
Publicado: (2014)

Anti-PD-1 antibody significantly increases therapeutic efficacy of Listeria monocytogenes (Lm)-LLO immunotherapy
por: Mkrtichyan, Mikayel, et al.
Publicado: (2013)

Immune combinational therapy targeting OX40 and IDO synergistically enhances efficacy of a cancer vaccine
por: Berrong, Zuzana, et al.
Publicado: (2014)

Pre-immature dendritic cells (PIDC) pulsed with HPV16 E6 or E7 peptide are capable of eliciting specific immune response in patients with advanced cervical cancer
por: Rahma, Osama E, et al.
Publicado: (2014)

Agonist anti-GITR antibody significantly enhances the therapeutic efficacy of Listeria monocytogenes-based immunotherapy
por: Shrimali, Rajeev, et al.
Publicado: (2017)

IDO Vaccine Ablates Immune-Suppressive Myeloid Populations and Enhances Antitumor Effects Independent of Tumor Cell IDO Status
por: Nandre, Rahul, et al.
Publicado: (2022)

SANTAVAC(TM): Summary of Research and Development
por: Lokhov, Petr G., et al.
Publicado: (2019)

Targeting the PI3K/Akt/mTOR pathway: A therapeutic strategy in COVID-19 patients
por: Abu-Eid, Rasha, et al.
Publicado: (2021)

Cytokine-driven Proliferation and Differentiation of Human Naive, Central Memory, and Effector Memory CD4(+) T Cells
por: Geginat, Jens, et al.
Publicado: (2001)

Counterconditioning following memory retrieval diminishes the reinstatement of appetitive memories in humans
por: Gera, Rani, et al.
Publicado: (2019)

Hoxb4 Overexpression in CD4 Memory Phenotype T Cells Increases the Central Memory Population upon Homeostatic Proliferation
por: Frison, Héloïse, et al.
Publicado: (2013)

Diminished Perisomatic GABAergic Terminals on Cortical Neurons Adjacent to Amyloid Plaques
por: Garcia-Marin, Virginia, et al.
Publicado: (2009)

Consequences of cognitive offloading: Boosting performance but diminishing memory
por: Grinschgl, Sandra, et al.
Publicado: (2021)

Deciphering the Role of Regulatory CD4 T Cells in Oral and Oropharyngeal Cancer: A Systematic Review
por: O'Higgins, Caoimhín, et al.
Publicado: (2018)

Strategies and designs for combination immune therapy
por: Khleif, Samir
Publicado: (2015)

CD57(+) Memory T Cells Proliferate In Vivo
por: Ahmed, Raya, et al.
Publicado: (2020)

Diminished Activation of Motor Working-Memory Networks in Parkinson's Disease
por: Rottschy, Claudia, et al.
Publicado: (2013)

High-dose treatment with ADXS11-001, a listeria monocytogenes (Lm)-listeriolysin O (LLO) immunotherapy, in women with cervical cancer
por: Ghamande, Sharad, et al.
Publicado: (2015)

Metabolic syndrome diminishes insulin-induced Akt activation and causes a redistribution of Akt-interacting proteins in cardiomyocytes
por: Landa-Galvan, Huguet V., et al.
Publicado: (2020)

Homeostatic Proliferation Fails to Efficiently Reactivate HIV-1 Latently Infected Central Memory CD4+ T Cells
por: Bosque, Alberto, et al.
Publicado: (2011)

Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8(+) T-cell memory in wild-type and humanized mice
por: Chen, Yuchao, et al.
Publicado: (2020)

HIV-1 Variation Diminishes CD4 T Lymphocyte Recognition
por: Harcourt, Gillian C., et al.
Publicado: (1998)

Memory Traces Diminished by Exercise Affect New Learning as Proactive Facilitation
por: Li, Cuicui, et al.
Publicado: (2020)

Phosphatidylinositol 3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals
por: Nicholson-Fish, Jessica C., et al.
Publicado: (2015)

Single variable domains from the T cell receptor β chain function as mono- and bifunctional CARs and TCRs
por: Oh, Julyun, et al.
Publicado: (2019)

A Therapeutic Vaccine Targeting Rat BORIS (CTCFL) for the Treatment of Rat Breast Cancer Tumors
por: Loukinov, Dmitri, et al.
Publicado: (2023)

Editorial: Advances in Head and Neck Cancer Immunology and Immunotherapy
por: Abu Eid, Rasha
Publicado: (2019)

Reducing AD-Like Pathology in 3xTg-AD Mouse Model by DNA Epitope Vaccine — A Novel Immunotherapeutic Strategy
por: Movsesyan, Nina, et al.
Publicado: (2008)

Diminished Memory T-Cell Expansion Due to Delayed Kinetics of Antigen Expression by Lentivectors
por: Furmanov, Karina, et al.
Publicado: (2013)

Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia
por: Braun, Urs, et al.
Publicado: (2021)

MicroRNA‐495‐3p diminishes doxorubicin‐induced cardiotoxicity through activating AKT
por: Meng, Jun, et al.
Publicado: (2022)

CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40
por: MacLeod, Megan, et al.
Publicado: (2006)

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
por: Fan, Z, et al.
Publicado: (2017)

Mannan-Abeta(28 )conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice
por: Petrushina, Irina, et al.
Publicado: (2008)

CPVT-associated cardiac ryanodine receptor mutation G357S with reduced penetrance impairs Ca(2+) release termination and diminishes protein expression
por: Liu, Yingjie, et al.
Publicado: (2017)

Role of PI3K/Akt signaling in memory CD8 T cell differentiation
por: Kim, Eui Ho, et al.
Publicado: (2013)

Antiangiogenic Treatment Diminishes Renal Injury and Dysfunction via Regulation of Local AKT in Early Experimental Diabetes
por: Bai, Xiaoyan, et al.
Publicado: (2014)

Induction of tumoricidal function in CD4(+) T cells is associated with concomitant memory and terminally differentiated phenotype
por: Hirschhorn-Cymerman, Daniel, et al.
Publicado: (2012)

Early CD8 T-cell memory precursors and terminal effectors exhibit equipotent in vivo degranulation
por: Yuzefpolskiy, Yevgeniy, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_oep0j1o23btoulkva467ga7oeg