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Human derived dimerization tag enhances tumor killing potency of a T-cell engaging bispecific antibody

Bispecific antibodies (BsAbs) have proven highly efficient T cell recruiters for cancer immunotherapy by virtue of one tumor antigen-reactive single chain variable fragment (scFv) and another that binds CD3. In order to enhance the antitumor potency of these tandem scFv BsAbs (tsc-BsAbs), we exploit...

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Detalles Bibliográficos
Autores principales:	Ahmed, Mahiuddin, Cheng, Ming, Cheung, Irene Y, Cheung, Nai-Kong V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485828/ https://www.ncbi.nlm.nih.gov/pubmed/26137406 http://dx.doi.org/10.4161/2162402X.2014.989776

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