New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity

Plasmacytoid dendritic cells (pDCs) are not only potent inflammatory cytokine producers but also function as antigen-presenting cells (APCs). We have shown that vaccination using CpG-B activated tumor antigen (Ag) presenting pDCs induce Th17 cells that promote intratumoral immune cell recruitment, i...

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Detalles Bibliográficos
Autores principales: Guéry, Leslie, Hugues, Stéphanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485838/
https://www.ncbi.nlm.nih.gov/pubmed/26155409
http://dx.doi.org/10.4161/2162402X.2014.988476
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author Guéry, Leslie
Hugues, Stéphanie
author_facet Guéry, Leslie
Hugues, Stéphanie
author_sort Guéry, Leslie
collection PubMed
description Plasmacytoid dendritic cells (pDCs) are not only potent inflammatory cytokine producers but also function as antigen-presenting cells (APCs). We have shown that vaccination using CpG-B activated tumor antigen (Ag) presenting pDCs induce Th17 cells that promote intratumoral immune cell recruitment, including antitumor cytotoxic T lymphocytes CTLs. Therefore, strategies targeting both innate and adaptive pDC functions may improve antitumor T-cell immunity.
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spelling pubmed-44858382016-02-03 New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity Guéry, Leslie Hugues, Stéphanie Oncoimmunology Author's View Plasmacytoid dendritic cells (pDCs) are not only potent inflammatory cytokine producers but also function as antigen-presenting cells (APCs). We have shown that vaccination using CpG-B activated tumor antigen (Ag) presenting pDCs induce Th17 cells that promote intratumoral immune cell recruitment, including antitumor cytotoxic T lymphocytes CTLs. Therefore, strategies targeting both innate and adaptive pDC functions may improve antitumor T-cell immunity. Taylor & Francis 2015-05-08 /pmc/articles/PMC4485838/ /pubmed/26155409 http://dx.doi.org/10.4161/2162402X.2014.988476 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Guéry, Leslie
Hugues, Stéphanie
New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity
title New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity
title_full New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity
title_fullStr New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity
title_full_unstemmed New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity
title_short New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity
title_sort new role for antigen-presenting activated pdcs in promoting th17 cells and impacting antitumor immunity
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485838/
https://www.ncbi.nlm.nih.gov/pubmed/26155409
http://dx.doi.org/10.4161/2162402X.2014.988476
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