Cargando…
A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors
BACKGROUND: Ovarian granulosa cell tumors are the most common sex-cord stromal tumors and have juvenile (JGCTs) and adult forms. In a previous study we reported the occurrence of activating somatic mutations of Gαs, which transduces mitogenic signals, in 30% of the analyzed JGCTs. METHODS: We have s...
Autores principales: | Bessière, Laurianne, Todeschini, Anne-Laure, Auguste, Aurélie, Sarnacki, Sabine, Flatters, Delphine, Legois, Bérangère, Sultan, Charles, Kalfa, Nicolas, Galmiche, Louise, Veitia, Reiner A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485906/ https://www.ncbi.nlm.nih.gov/pubmed/26137586 http://dx.doi.org/10.1016/j.ebiom.2015.03.002 |
Ejemplares similares
-
The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells
por: Georges, Adrien, et al.
Publicado: (2014) -
The new molecular biology of granulosa cell tumors of the ovary
por: Kalfa, Nicolas, et al.
Publicado: (2009) -
A truncating MEIOB mutation responsible for familial primary ovarian insufficiency abolishes its interaction with its partner SPATA22 and their recruitment to DNA double-strand breaks
por: Caburet, Sandrine, et al.
Publicado: (2019) -
Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes
por: Caburet, Sandrine, et al.
Publicado: (2015) -
Precocious Pseudo-puberty in a Two-year-old Girl, Presenting with Bilateral Ovarian Enlargement and Progressing to Unilateral Juvenile Granulosa Cell Tumour
por: Barakizou, Hager, et al.
Publicado: (2022)