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Chlorhexidine hexametaphosphate nanoparticles as a novel antimicrobial coating for dental implants
Dental implants are an increasingly popular solution to missing teeth. Implants are prone to colonisation by pathogenic oral bacteria which can lead to inflammation, destruction of bone and ultimately implant failure. The aim of this study was to investigate the use of chlorhexidine (CHX) hexametaph...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486094/ https://www.ncbi.nlm.nih.gov/pubmed/26123234 http://dx.doi.org/10.1007/s10856-015-5532-1 |
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author | Wood, Natalie J. Jenkinson, Howard F. Davis, Sean A. Mann, Stephen O’Sullivan, Dominic J. Barbour, Michele E. |
author_facet | Wood, Natalie J. Jenkinson, Howard F. Davis, Sean A. Mann, Stephen O’Sullivan, Dominic J. Barbour, Michele E. |
author_sort | Wood, Natalie J. |
collection | PubMed |
description | Dental implants are an increasingly popular solution to missing teeth. Implants are prone to colonisation by pathogenic oral bacteria which can lead to inflammation, destruction of bone and ultimately implant failure. The aim of this study was to investigate the use of chlorhexidine (CHX) hexametaphosphate (HMP) nanoparticles (NPs) with a total CHX concentration equivalent to 5 mM as a coating for dental implants. The CHX HMP NPs had mean diameter 49 nm and composition was confirmed showing presence of both chlorine and phosphorus. The NPs formed micrometer-sized aggregated surface deposits on commercially pure grade II titanium substrates following immersion–coating for 30 s. When CHX HMP NP-coated titanium specimens were immersed in deionised water, sustained release of soluble CHX was observed, both in the absence and presence of a salivary pellicle, for the duration of the study (99 days) without reaching a plateau. Control specimens exposed to a solution of aqueous 25 µM CHX (equivalent to the residual aqueous CHX present with the NPs) did not exhibit CHX release. CHX HMP NP-coated surfaces exhibited antimicrobial efficacy against oral primary colonising bacterium Streptococcus gordonii within 8 h. The antimicrobial efficacy was greater in the presence of an acquired pellicle which is postulated to be due to retention of soluble CHX by the pellicle. |
format | Online Article Text |
id | pubmed-4486094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-44860942015-07-07 Chlorhexidine hexametaphosphate nanoparticles as a novel antimicrobial coating for dental implants Wood, Natalie J. Jenkinson, Howard F. Davis, Sean A. Mann, Stephen O’Sullivan, Dominic J. Barbour, Michele E. J Mater Sci Mater Med Engineering and Nano-engineering Approaches for Medical Devices Dental implants are an increasingly popular solution to missing teeth. Implants are prone to colonisation by pathogenic oral bacteria which can lead to inflammation, destruction of bone and ultimately implant failure. The aim of this study was to investigate the use of chlorhexidine (CHX) hexametaphosphate (HMP) nanoparticles (NPs) with a total CHX concentration equivalent to 5 mM as a coating for dental implants. The CHX HMP NPs had mean diameter 49 nm and composition was confirmed showing presence of both chlorine and phosphorus. The NPs formed micrometer-sized aggregated surface deposits on commercially pure grade II titanium substrates following immersion–coating for 30 s. When CHX HMP NP-coated titanium specimens were immersed in deionised water, sustained release of soluble CHX was observed, both in the absence and presence of a salivary pellicle, for the duration of the study (99 days) without reaching a plateau. Control specimens exposed to a solution of aqueous 25 µM CHX (equivalent to the residual aqueous CHX present with the NPs) did not exhibit CHX release. CHX HMP NP-coated surfaces exhibited antimicrobial efficacy against oral primary colonising bacterium Streptococcus gordonii within 8 h. The antimicrobial efficacy was greater in the presence of an acquired pellicle which is postulated to be due to retention of soluble CHX by the pellicle. Springer US 2015-06-30 2015 /pmc/articles/PMC4486094/ /pubmed/26123234 http://dx.doi.org/10.1007/s10856-015-5532-1 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Engineering and Nano-engineering Approaches for Medical Devices Wood, Natalie J. Jenkinson, Howard F. Davis, Sean A. Mann, Stephen O’Sullivan, Dominic J. Barbour, Michele E. Chlorhexidine hexametaphosphate nanoparticles as a novel antimicrobial coating for dental implants |
title | Chlorhexidine hexametaphosphate nanoparticles as a novel antimicrobial coating for dental implants |
title_full | Chlorhexidine hexametaphosphate nanoparticles as a novel antimicrobial coating for dental implants |
title_fullStr | Chlorhexidine hexametaphosphate nanoparticles as a novel antimicrobial coating for dental implants |
title_full_unstemmed | Chlorhexidine hexametaphosphate nanoparticles as a novel antimicrobial coating for dental implants |
title_short | Chlorhexidine hexametaphosphate nanoparticles as a novel antimicrobial coating for dental implants |
title_sort | chlorhexidine hexametaphosphate nanoparticles as a novel antimicrobial coating for dental implants |
topic | Engineering and Nano-engineering Approaches for Medical Devices |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486094/ https://www.ncbi.nlm.nih.gov/pubmed/26123234 http://dx.doi.org/10.1007/s10856-015-5532-1 |
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